Stress proteins in aging and life span.
TLDR
Among many signalling mechanisms involved in altering longevity and aging, the insulin/IGF-1 pathway and the Sir2 deacetylase are highly significant and an enquires into the role of some of these pathways in longevity/aging along with HSP.Abstract:
Heat shock proteins (HSP) are molecular chaperones and have been implicated in longevity and aging in many species. Their major functions include chaperoning misfolded or newly synthesised polypeptides, protecting cells from proteotoxic stress, and processing of immunogenic agents. These proteins are expressed constitutively and can be induced by stresses such as heat, oxidative stress and many more. The induction of HSP in aging could potentially maintain protein homeostasis and longevity by refolding the damaged proteins which accumulate during aging and are toxic to cells. HSP are shown to increase life span in model organisms such as Caenorhabditis elegans and decrease aging-related proteotoxicity. Thus, decrease in HSP in aging is associated with disruption of cellular homeostasis which causes diseases such as cancer, cell senescence and neurodegeneration. HSP levels are decreased with aging in most organs including neurons. Aging also causes attenuation or alteration of many signalling pathw...read more
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The Biology of Aging and Cancer: A Brief Overview of Shared and Divergent Molecular Hallmarks
TL;DR: It is now clear that aging and cancer development either share or diverge in several disease mechanisms, and aging can be considered an aging disease, though the shared mechanisms underpinning the two processes remain unclear.
Journal ArticleDOI
Plasma membranes as heat stress sensors: From lipid-controlled molecular switches to therapeutic applications☆ , ☆☆
Zsolt Török,Tim Crul,Bruno Maresca,Gerhard J. Schütz,Félix Viana,Laura Dindia,Stefano Piotto,Mario Brameshuber,Gábor Balogh,Mária Péter,Amalia Porta,Alfonso Trapani,Imre Gombos,Attila Glatz,Burcin Gungor,Begüm Peksel,László Vígh,Bálint Csoboz,Ibolya Horváth,Mathilakath M. Vijayan,Phillip L. Hooper,John L. Harwood +21 more
TL;DR: The classic heat shock (stress) response (HSR) was originally attributed to protein denaturation, but it is observed that a deregulated HSR is found in a large number of important diseases where more detailed knowledge of the molecular mechanisms involved may offer timely opportunities for clinical interventions and new, innovative drug treatments.
Journal ArticleDOI
Roles of Extracellular HSPs as Biomarkers in Immune Surveillance and Immune Evasion
TL;DR: Release of ex-HSP and HSP-rich oncosomes are essential in RASP, by which molecular co-transfer of HSPs with oncogenic factors to recipient cells can promote cancer progression and resistance against stresses such as hypoxia, radiation, drugs, and immune systems.
Journal ArticleDOI
HSP-enriched properties of extracellular vesicles involve survival of metastatic oral cancer cells
Kisho Ono,Takanori Eguchi,Chiharu Sogawa,Stuart K. Calderwood,Junya Futagawa,Tomonari Kasai,Masaharu Seno,Kuniaki Okamoto,Akira Sasaki,Ken ichi Kozaki +9 more
TL;DR: Elevated HSP90 levels in secreted vesicles are potential prognostic biomarkers and therapeutic targets in metastatic OSCC.
Journal ArticleDOI
Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection
TL;DR: Although each is regulated by distinct mechanisms, it is emerging that these transcription factors engage in crosstalk by sharing overlapping transcriptional targets, such as heat shock protein (HSP)70, p62, and activating transcription factor (ATF)3, and in certain cases, compensating for each other.
References
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Journal ArticleDOI
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Journal ArticleDOI
Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications
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