TGF-β Receptor Inhibitors Target the CD44high/Id1high Glioma-Initiating Cell Population in Human Glioblastoma
Judit Anido,Andrea Sáez-Borderías,Alba Gonzalez-Junca,Laura Rodon,Gerard Folch,Maria Ángeles Carmona,Rosa M. Prieto-Sánchez,Ignasi Barba,Elena Martínez-Sáez,Ludmila Prudkin,Isabel Cuartas,C. Raventós,Francisco Martínez-Ricarte,M. Antonia Poca,David Garcia-Dorado,Michael Lahn,Jonathan M. Yingling,Jordi Rodon,Juan Sahuquillo,Juan Sahuquillo,José Baselga,Joan Seoane,Joan Seoane +22 more
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TLDR
A cell population enriched for GICs that expresses high levels of CD44 and Id1 and tend to be located in a perivascular niche is identified, which confer poor prognosis in GBM patients.About:
This article is published in Cancer Cell.The article was published on 2010-12-14 and is currently open access. It has received 504 citations till now. The article focuses on the topics: Glioma & Population.read more
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TGFβ signalling in context.
TL;DR: The basic elements of the transforming growth factor-β (TGFβ) pathway were revealed and the concept of how the TGFβ signal travels from the membrane to the nucleus has been enriched with additional findings.
Journal ArticleDOI
Patient-derived xenograft models: an emerging platform for translational cancer research.
Manuel Hidalgo,Frédéric Amant,Andrew V. Biankin,Eva Budinská,Annette T. Byrne,Carlos Caldas,Robert Clarke,Steven de Jong,Jos Jonkers,Gunhild Mari Mælandsmo,Sergio Roman-Roman,Joan Seoane,Livio Trusolino,Alberto Villanueva +13 more
TL;DR: The current state of the art in this field is summarized, including methodologic issues, available collections, practical applications, challenges and shortcomings, and future directions, and a European consortium of PDX models is introduced.
Journal ArticleDOI
Cancer stem cells in glioblastoma
Justin D. Lathia,Justin D. Lathia,Stephen C. Mack,Erin E. Mulkearns-Hubert,Claudia L.L. Valentim,Jeremy N. Rich,Jeremy N. Rich +6 more
TL;DR: To fulfill the future goal of developing novel therapies to collapse CSC dynamics, drawing parallels to other normal and pathological states that are highly interactive with their microenvironments and that use developmental signaling pathways will be beneficial.
Journal ArticleDOI
Targeting the TGFβ signalling pathway in disease.
Rosemary J. Akhurst,Akiko Hata +1 more
TL;DR: Why the TGFβ signalling pathway is a drug target, the potential clinical applications of TGF β inhibition, the issues arising with anti-TGFβ therapy and how these might be tackled using personalized approaches to dosing, monitoring of biomarkers as well as brief and/or localized drug-dosing regimens are considered.
Journal ArticleDOI
The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?
Vicki Plaks,Niwen Kong,Zena Werb +2 more
TL;DR: This work focuses on the CSC niche and discusses its contribution to tumor initiation and progression and examines the prospects of targeting the niche components as preferable therapeutic targets.
References
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Journal ArticleDOI
Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma
Roger Stupp,Warren P. Mason,Martin J. van den Bent,Michael Weller,Barbara Fisher,Martin J.B. Taphoorn,Karl Belanger,Alba A. Brandes,Christine Marosi,Ulrich Bogdahn,Jürgen Curschmann,Robert C. Janzer,Samuel K. Ludwin,Thierry Gorlia,Anouk Allgeier,Denis Lacombe,J. Gregory Cairncross,Elizabeth Eisenhauer,René O. Mirimanoff +18 more
TL;DR: The addition of temozolomide to radiotherapy for newly diagnosed glioblastoma resulted in a clinically meaningful and statistically significant survival benefit with minimal additional toxicity.
Journal ArticleDOI
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Sendurai A. Mani,Wenjun Guo,Mai Jing Liao,Elinor Ng Eaton,Ayyakkannu Ayyanan,Alicia Y. Zhou,Mary W. Brooks,Ferenc Reinhard,Cheng Cheng Zhang,Michail Shipitsin,Lauren L. Campbell,Kornelia Polyak,Cathrin Brisken,Jing Yang,Robert A. Weinberg +14 more
TL;DR: It is reported that the induction of an EMT in immortalized human mammary epithelial cells (HMLEs) results in the acquisition of mesenchymal traits and in the expression of stem-cell markers, and it is shown that those cells have an increased ability to form mammospheres, a property associated with mammARY epithelial stem cells.
Journal ArticleDOI
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
Shideng Bao,Qiulian Wu,Roger E. McLendon,Yueling Hao,Qing Ming Shi,Anita B. Hjelmeland,Mark W. Dewhirst,Darell D. Bigner,Jeremy N. Rich +8 more
TL;DR: This work shows that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity, and suggests that CD133-positive tumour cells could be the source of tumour recurrence after radiation.
Journal ArticleDOI
TGFβ in Cancer
TL;DR: The mechanistic basis and clinical relevance of TGFbeta's role in cancer is becoming increasingly clear, paving the way for a better understanding of the complexity and therapeutic potential of this pathway.
Journal ArticleDOI
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
TL;DR: The cancer stem cell (CSC) hypothesis provides an attractive cellular mechanism to account for the therapeutic refractoriness and dormant behaviour exhibited by many of these tumours.
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