Th17 cells and regulatory T cells in elite control over HIV and SIV.
Reads0
Chats0
TLDR
Interactions between Th17 cells, T-reg, and cells of the innate immune system influence the course of HIV and SIV infection from its earliest stages, even before the appearance of adaptive immunity.Abstract:
Purpose of reviewWe present current findings about two subsets of CD4+ T cells that play an important part in the initial host response to infection with the HIV type 1: those producing IL-17 (Th17 cells) and those with immunosuppressive function (CD25+FoxP3+ regulatory T cells or T-reg). The role oread more
Citations
More filters
Journal ArticleDOI
Tobacco Smoke Induces and Alters Immune Responses in the Lung Triggering Inflammation, Allergy, Asthma and Other Lung Diseases: A Mechanistic Review
TL;DR: It is demonstrated how the imbalance between oxidants and antioxidants resulting from exposure to tobacco smoke leads to oxidative stress, increased mucosal inflammation, and increased expression of inflammatory cytokines (such as interleukin (IL)-8, IL-6 and tumor necrosis factor α ([TNF]-α).
Journal ArticleDOI
Initiation of ART during Early Acute HIV Infection Preserves Mucosal Th17 Function and Reverses HIV-Related Immune Activation
Alexandra Schuetz,Claire Deleage,Irini Sereti,Rungsun Rerknimitr,Nittaya Phanuphak,Yuwadee Phuang-Ngern,Jacob D. Estes,Netanya G. Sandler,Suchada Sukhumvittaya,Mary A. Marovich,Surat Jongrakthaitae,Siriwat Akapirat,James L. K. Fletscher,Eugene Kroon,Robin Dewar,Rapee Trichavaroj,Nitiya Chomchey,Daniel C. Douek,Robert J. O′Connell,Viseth Ngauy,Merlin L. Robb,Praphan Phanuphak,Nelson L. Michael,Jean-Louis Excler,Jerome H. Kim,Mark de Souza,Jintanat Ananworanich,Search Study Groups +27 more
TL;DR: Data support a loss of Th17 cells at early stages of acute HIV infection, and highlight that studies of ART initiation during early AHI should be further explored to assess the underlying mechanism of mucosal Th17 function preservation.
Journal ArticleDOI
Tuberculosis and HIV Coinfection
TL;DR: The clinical management of HIV-associated TB includes the integration of effective anti-TB treatment, use of concurrent antiretroviral therapy (ART), prevention of HIV -related comorbidities, management of drug cytotoxicity, and prevention/treatment of immune reconstitution inflammatory syndrome (IRIS).
Journal ArticleDOI
Intracellular Pathogens: Host Immunity and Microbial Persistence Strategies
TL;DR: An overview of the immune effector functions used by the host to counter pathogens and various persistence strategies used by intracellular pathogens to counter host immunity are provided, which enables their extended period of colonization in the host.
Journal ArticleDOI
Incomplete Immune Recovery in HIV Infection: Mechanisms, Relevance for Clinical Care, and Possible Solutions
TL;DR: The known and unknown factors regarding the incomplete immune reconstitution in HIV infection are summarized, including mechanisms, relevance for clinical care, and possible solutions.
References
More filters
Journal ArticleDOI
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
TL;DR: Foxp3, which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in naturally arising CD4+ regulatory T cells and retroviral gene transfer of Foxp3 converts naïve T cells toward a regulatory T cell phenotype similar to that of naturally occurring CD4+.
Journal ArticleDOI
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
Estelle Bettelli,Yijun Carrier,Wenda Gao,Thomas Korn,Terry B. Strom,Mohamed Oukka,Howard L. Weiner,Vijay K. Kuchroo +7 more
TL;DR: It is shown that IL-6, an acute phase protein induced during inflammation, completely inhibits the generation of Foxp3+ Treg cells induced by TGF-β, and the data demonstrate a dichotomy in thegeneration of pathogenic (TH17) T cells that induce autoimmunity and regulatory (Foxp3+) T Cells that inhibit autoimmune tissue injury.
Journal ArticleDOI
Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3
Wanjun Chen,Wenwen Jin,Neil J. Hardegen,Ke Jian Lei,Li Li,Nancy J. Marinos,George McGrady,Sharon M. Wahl +7 more
TL;DR: Novel evidence is presented that conversion of naive peripheral CD4+CD25− T cells into anergic/suppressor cells that are CD25+, CD45RB−/low and intracellular CTLA-4+ can be achieved through costimulation with T cell receptors (TCRs) and transforming growth factor β (TGF-β).
Journal ArticleDOI
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.
Ivaylo I. Ivanov,Brent S. McKenzie,Liang Zhou,Carlos E. Tadokoro,Alice Lepelley,Juan J. Lafaille,Daniel J. Cua,Dan R. Littman +7 more
TL;DR: It is shown that the orphan nuclear receptor RORgammat is the key transcription factor that orchestrates the differentiation of this effector cell lineage of proinflammatory T helper cells and its potential as a therapeutic target in inflammatory diseases is highlighted.
Journal ArticleDOI
TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-Producing T cells
Marc Veldhoen,Richard J. Hocking,Christopher J. Atkins,Richard M. Locksley,Brigitta Stockinger +4 more
TL;DR: The data indicate that, in the presence of IL-6, TGFbeta1 subverts Th1 and Th2 differentiation for the generation ofIL-17-producing T cells.
Related Papers (5)
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Jason M. Brenchley,David Price,Timothy W. Schacker,Tedi E. Asher,Guido Silvestri,Srinivas S. Rao,Zachary Kazzaz,Ethan Bornstein,Olivier Lambotte,Daniel M. Altmann,Bruce R. Blazar,Benigno Rodriguez,Leia Teixeira-Johnson,Alan L. Landay,Jeffrey N. Martin,Frederick Hecht,Louis J. Picker,Michael M. Lederman,Steven G. Deeks,Daniel C. Douek +19 more