The AP-1 transcriptional complex: Local switch or remote command?
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TLDR
These studies strikingly indicate that AP-1 principally operates as a remote command binding to distal enhancers, placing chromatin architecture dynamics at the heart of its transcriptional actions.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2019-08-01 and is currently open access. It has received 128 citations till now. The article focuses on the topics: Enhancer & Transcription factor.read more
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Oxidative Stress in Cancer.
TL;DR: During progression and metastasis, tumor cells adapt to oxidative stress by increasing NADPH in various ways, including activation of AMPK, the PPP, and reductive glutamine and folate metabolism.
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Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome.
Sara Lago,Matteo Nadai,Filippo M. Cernilogar,Maryam Kazerani,Helena Domíniguez Moreno,Gunnar Schotta,Sara N. Richter +6 more
TL;DR: In this article, DNA G-quadruplex (G4)-folded regions in cells were reported to be associated with either increased or decreased transcriptional activity in liposarcoma cells.
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Regulation of SIRT1 and Its Roles in Inflammation
TL;DR: The mechanisms that regulate SIRT1 expression, including upstream activators and suppressors that operate on the transcriptional and post-transcriptional levels, are summarized and the potential for Sirt1-based therapeutics for inflammatory diseases is highlighted.
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The Multifaceted Output of c-Jun Biological Activity: Focus at the Junction of CD8 T Cell Activation and Exhaustion
TL;DR: How transcriptional and epigenetic regulatory mechanisms underlie the multifaceted output of c-Jun biological activity, eliciting quite distinct cellular responses, such as neoplastic transformation, differentiation and apoptosis, in different cell types are reviewed.
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The nuclear oncoprotein Fra-1: a transcription factor knocking on therapeutic applications' door.
TL;DR: The state of the art and emerging topics and perspectives on FOSL1 and its gene product are reviewed and several recent reports showing the emerging roles of Fra-1 in the mechanisms of both resistance and addiction to targeted therapies are discussed.
References
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Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome.
Nathaniel D. Heintzman,Rhona K. Stuart,Gary C. Hon,Yutao Fu,Christina W. Ching,R. David Hawkins,Leah O. Barrera,Sara Van Calcar,Chunxu Qu,Keith A. Ching,Wei Wang,Zhiping Weng,Roland Green,Gregory E. Crawford,Bing Ren +14 more
TL;DR: Insight is given into the connections between chromatin modifications and transcriptional regulatory activity and a novel functional enhancer for the carnitine transporter SLC22A5 (OCTN2) is uncovered, providing a new tool for the functional annotation of the human genome.
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AP-1 as a regulator of cell life and death
Eitan Shaulian,Michael Karin +1 more
TL;DR: Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour suppressors, as well as upregulation of positive cell cycle regulators, whereas JunB has the converse effect.
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The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases
TL;DR: The specific roles of three MAPKs, namely ERK, JNK and FRK, in modulation of both the level and activity of AP-1, are discussed.
Journal ArticleDOI
An atlas of active enhancers across human cell types and tissues
Robin Andersson,Claudia Gebhard,Irene Miguel-Escalada,Ilka Hoof,Jette Bornholdt,Mette Boyd,Yun Chen,Xiaobei Zhao,Xiaobei Zhao,Christian Schmidl,Takahiro Suzuki,Evgenia Ntini,Erik Arner,Eivind Valen,Eivind Valen,Kang Li,Lucia Schwarzfischer,Dagmar Glatz,Johanna Raithel,Berit Lilje,Nicolas Rapin,Frederik Otzen Bagger,Mette Rose Jørgensen,Peter Refsing Andersen,Nicolas Bertin,Owen J. L. Rackham,A. Maxwell Burroughs,J Kenneth Baillie,Yuri Ishizu,Yuri Shimizu,Erina Furuhata,Shiori Maeda,Yutaka Negishi,Christopher J. Mungall,Terrence F. Meehan,Timo Lassmann,Masayoshi Itoh,Hideya Kawaji,Naoto Kondo,Jun Kawai,Andreas Lennartsson,Carsten O. Daub,Peter Heutink,David A. Hume,Torben Heick Jensen,Harukazu Suzuki,Yoshihide Hayashizaki,Ferenc Müller,Alistair R. R. Forrest,Piero Carninci,Michael Rehli,Albin Sandelin +51 more
TL;DR: It is shown that enhancers share properties with CpG-poor messenger RNA promoters but produce bidirectional, exosome-sensitive, relatively short unspliced RNAs, the generation of which is strongly related to enhancer activity.
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AP-1: a double-edged sword in tumorigenesis
Robert Eferl,Erwin F. Wagner +1 more
TL;DR: This work focuses on the JUN and FOS proteins and aims to offer a new perspective on the molecular mechanisms that regulate the oncogenic and anti-oncogenic effects of AP-1 in tumour development.