Journal ArticleDOI
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
Jon M. Hanifin,Thurston M,Thurston M,Omoto M,Omoto M,R. Cherill,R. Cherill,Susan J. Tofte,Graeber M,Graeber M +9 more
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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.Abstract:
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.read more
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Journal ArticleDOI
Single nucleotide variations in genes associated with innate immunity are enriched in Japanese adult cases of face and neck type atopic dermatitis.
Fumiyo Yasuda-Sekiguchi,Aiko Shiohama,Ayano Fukushima,Shoko Obata,Naoko Mochimaru,Aki Honda,Hiroshi Kawasaki,Akiharu Kubo,Tamotsu Ebihara,Masayuki Amagai,Takashi Sasaki +10 more
TL;DR: These findings revealed that the SNVs in genes associated with the innate immune pathway are enriched in a subgroup of AD, suggesting the combinational approach of clinical subgrouping and genotyping is valuable for detecting novel disease-associated genetic factors.
Patent
Compositions for the treatment of skin conditions
TL;DR: In this article, the authors described methods and compositions for the treatment of skin conditions associated with dysbiosis, and the use of metabolites for treatment of dysregulated microbiota in a subject.
Journal ArticleDOI
Association study of transition of laboratory marker levels and transition of disease activity of atopic dermatitis patients treated with dupilumab.
Maki Mizuno,Go Horiguchi,Satoshi Teramukai,Susumu Ichiyama,Michiko Ito,Toshihiko Hoashi,Naoko Kanda,Hidehisa Saeki +7 more
TL;DR: In this article, the association of the transition of laboratory marker levels and transition of disease activity in dupilumab-treated atopic dermatitis (AD) patients was investigated.
Journal ArticleDOI
Paediatric atopic eczema (atopic dermatitis) in South Africa: A practical algorithm for the management of mild-to-moderate disease in daily clinical practice.
Susanna M H Kannenberg,S. Karabus,Willem I Visser,Jamilabibi Aboobaker,Magdalena M Kriel,Michael Levin,Basil Magigaba,Ahmed I. Manjra,Rupesh Misra,Pholile Mpofu,Azwitamisi Tshigabe,Thomas A. Luger +11 more
TL;DR: This algorithm aims to simplify treatment of paediatric AE, optimising clinical outcomes and reducing disease burden by excluding treatment of patients with severe AE, who should be referred to specialist care.
Book ChapterDOI
Defining and Measuring the Scope of Atopic Dermatitis.
Mary E. Laird,Kristen Lo Sicco +1 more
TL;DR: Assessment of AD-associated comorbidities, including allergic/immunologic conditions, psychiatric disorders, and metabolic/cardiac conditions, is important when evaluating this patient population.
References
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TL;DR: The Parallel Groups Design as mentioned in this paper is a special case of the Parallel Groups Study, and it is used to control for prognostic variables in linear regression analysis of linear regressions of linear models.
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Journal ArticleDOI
Severity Scoring of Atopic Dermatitis: The SCORAD Index
K.U. Schallreuter,Ch. Levenig,J. Berger,J. Umbert,R.K. Winkelmann,L. Wegener,O. Correia,Olivier Chosidow,P. Saiag,S. Bastuji-Garin,J. Revuz,Jean-Claude Roujeau,R. Situ,D.R. Inman,S.E.G. Fligiel,J. Varani,R.E. Schopf,J. Dobmeyer,T. Dobmeyer,B. Morsches,K. Holubar,G.E. Piérard,O. Bongard,H. Bounameaux,P. Corcuff,J.-L. Lévêque,J. Brasch,E. Christophers,G.T. Nahass,M. Sisto,S.A. Wagner,R.U. Peter,O. Adam,T. Ruzicka,J. McGrath,N.P. Burrows,R. Russell Jones,R.A.J. Eady,S. Veraldi,G. Rizzitelli,G. Lunghi,R. Cardone,R.M. Trüeb,G. Burg,F. Wantke,G. Fleischl,M. Götz,R. Jarisch,G. Tadini,E. Ermacora,S. Cambiaghi,A. Brusasco,R. Cavalli +52 more
TL;DR: Assessment methods for atopic dermatitis are not standardized, and therapeutic studies are difficult to interpret, so consensus on these methods is needed to obtain a consensus on them.
Journal ArticleDOI
Large sample standard errors of kappa and weighted kappa.
TL;DR: The statistics kappa and weighted kappa (Cohen, 1960) were introduced to provide coefficients of agreement between two raters for nominal scales as discussed by the authors, and they were used to provide a measure of the relative seriousness of the different possible disagreements.
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