Journal ArticleDOI
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
Jon M. Hanifin,Thurston M,Thurston M,Omoto M,Omoto M,R. Cherill,R. Cherill,Susan J. Tofte,Graeber M,Graeber M +9 more
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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.Abstract:
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.read more
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A real-world study of the longitudinal course of adult atopic dermatitis severity in clinical practice
Mindy R Hong,Donald Lei,Muhammad Yousaf,Rajeev Chavda,Sylvie Gabriel,Sherief R. Janmohamed,Jonathan I. Silverberg,Jonathan I. Silverberg +7 more
TL;DR: AD lesional severity has a heterogeneous longitudinal course and most patients with moderate-severe disease at baseline were unable to achieve persistent lesional clearance, while many patients had fluctuatingLesional severity scores over time.
Journal ArticleDOI
Vitreoscilla filiformis bacterial extract to improve the efficacy of emollient used in atopic dermatitis symptoms
TL;DR: In a 43-year-old woman with severe skin manifestations, it is confirmed a recurrent missense mutation 1031G → A, 5 resulting in a non-conservative amino acid change at the phosphorylation site and it is postulated that the penetrance of this mutation could not powerfully cause the disease phenotype before the age of onset.
Journal ArticleDOI
Clinical practice guide for the treatment of perforating dermatosis
Tamihiro Kawakami,Masashi Akiyama,Akemi Ishida-Yamamoto,Hajime Nakano,Chikage Mitoma,Kozo Yoneda,Yasushi Suga +6 more
TL;DR: The Japanese guideline for treatment of perforating dermatoses was updated using the Medical Information Network Distribution Service (MINDS) methodology and diagnostic criteria and severity classification were established.
Journal ArticleDOI
An update to the 2013-2014 American Academy of Dermatology (AAD) guidelines for the pharmacological management of atopic dermatitis.
TL;DR: In this paper, the authors explore the updated efficacy and safety data on established therapeutic options for AD including topical corticosteroids, topical calcineurin inhibitors, cyclosporine, azathioprine, methotrexate, and mycophenolate mofetil.
Journal ArticleDOI
Calcineurin inhibitors in the treatment of allergic dermatitis
TL;DR: In this paper, the role of calcineurin inhibitors in the treatment of allergic dermatitis, focusing on mechanisms of action, efficacy and topical and systemic adverse effects, was reviewed.
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Severity Scoring of Atopic Dermatitis: The SCORAD Index
K.U. Schallreuter,Ch. Levenig,J. Berger,J. Umbert,R.K. Winkelmann,L. Wegener,O. Correia,Olivier Chosidow,P. Saiag,S. Bastuji-Garin,J. Revuz,Jean-Claude Roujeau,R. Situ,D.R. Inman,S.E.G. Fligiel,J. Varani,R.E. Schopf,J. Dobmeyer,T. Dobmeyer,B. Morsches,K. Holubar,G.E. Piérard,O. Bongard,H. Bounameaux,P. Corcuff,J.-L. Lévêque,J. Brasch,E. Christophers,G.T. Nahass,M. Sisto,S.A. Wagner,R.U. Peter,O. Adam,T. Ruzicka,J. McGrath,N.P. Burrows,R. Russell Jones,R.A.J. Eady,S. Veraldi,G. Rizzitelli,G. Lunghi,R. Cardone,R.M. Trüeb,G. Burg,F. Wantke,G. Fleischl,M. Götz,R. Jarisch,G. Tadini,E. Ermacora,S. Cambiaghi,A. Brusasco,R. Cavalli +52 more
TL;DR: Assessment methods for atopic dermatitis are not standardized, and therapeutic studies are difficult to interpret, so consensus on these methods is needed to obtain a consensus on them.
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