Journal ArticleDOI
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
Jon M. Hanifin,Thurston M,Thurston M,Omoto M,Omoto M,R. Cherill,R. Cherill,Susan J. Tofte,Graeber M,Graeber M +9 more
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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.Abstract:
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.read more
Citations
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Journal ArticleDOI
Peak Pruritus Numerical Rating Scale: psychometric validation and responder definition for assessing itch in moderate-to-severe atopic dermatitis.
Gil Yosipovitch,M. Reaney,Vera Mastey,Laurent Eckert,A. Abbé,Lauren Nelson,M. Clark,N. Williams,Zhen Chen,Marius Ardeleanu,Bolanle Akinlade,N.M.H. Graham,Gianluca Pirozzi,Heribert Staudinger,S. Plaum,Allen Radin,Abhijit Gadkari +16 more
TL;DR: The Peak Pruritus Numerical Rating Scale (NRS) was developed and validated as a single‐item, patient‐reported outcome (PRO) of itch severity.
Journal ArticleDOI
Distinct patterns of brain activity evoked by histamine-induced itch reveal an association with itch intensity and disease severity in atopic dermatitis.
Yozo Ishiuji,Robert C. Coghill,Tejesh Patel,Yoshitetsu Oshiro,Robert A. Kraft,G. Yosipovitch +5 more
TL;DR: This animal study highlights the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals, not necessarily belonging to the same breeds.
Journal ArticleDOI
Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment: Disease control with 0.1% tacrolimus ointment
A. Wollenberg,Sakari Reitamo,Giampiero Girolomoni,M. Lahfa,Thomas Ruzicka,Eugene Healy,Alberto Giannetti,T. Bieber,J. Vyas,M. Deleuran +9 more
TL;DR: Whether the proactive use of 0.1% tacrolimus ointment applied twice weekly can keep AD in remission and reduce the incidence of disease exacerbations (DE) is investigated.
Journal ArticleDOI
Validation of the Eczema Area and Severity Index for atopic dermatitis in a cohort of 1550 patients from the pimecrolimus cream 1% randomized controlled clinical trials programme.
Nathalie Barbier,Carle Paul,Thomas A. Luger,R. Allen,Y. De Prost,Kim A. Papp,Lawrence F. Eichenfield,Robert Cherill,Jon M. Hanifin +8 more
TL;DR: The Eczema Area and Severity Index is validated by assessing its internal consistency, reliability and sensitivity to change and by correlating it to other efficacy parameters.
Journal ArticleDOI
Delgocitinib ointment, a topical Janus kinase inhibitor, in adult patients with moderate to severe atopic dermatitis: A phase 3, randomized, double-blind, vehicle-controlled study and an open-label, long-term extension study
TL;DR: Delgocitinib ointment was effective and well tolerated in Japanese adult patients with moderate to severe AD for up to 28 weeks and the improvement in modified Eczema Area and Severity Index score was maintained in part 2.
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