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The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis

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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.
Abstract
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.

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Real-life experience on effectiveness and safety of dupilumab in adult patients with moderate-to-severe atopic dermatitis

TL;DR: Dupilumab significantly improved disease severity, pruritus, sleep loss and quality of life with an acceptable safety profile in adults with moderate-to-severe AD in a real-life Italian multicentre retrospective cohort.
Journal ArticleDOI

Topical pimecrolimus: a review of its clinical potential in the management of atopic dermatitis.

TL;DR: Topical pimecrolimus 1.0% cream provides a promising and well tolerated treatment option in the management of infants, children and adults with mild to moderate atopic dermatitis, and has shown no potential for skin atrophy.
Journal ArticleDOI

Onset of action of pimecrolimus cream 1% in the treatment of atopic eczema in infants

TL;DR: Pimecrolimus cream 1% was well tolerated and effective in patients with mild to very severe atopic eczema, with rapid onset of action and no disease rebound after discontinuation.
Journal ArticleDOI

The Validated Investigator Global Assessment for Atopic Dermatitis (vIGA-AD): The development and reliability testing of a novel clinical outcome measurement instrument for the severity of atopic dermatitis.

TL;DR: A validated IGA scale and training module were developed with the intent of harmonizing assessment of disease severity in AD trials, and strong reliability and excellent agreement between assessments were observed.
Journal ArticleDOI

A randomized controlled trial of pimecrolimus cream 1% in adolescents and adults with head and neck atopic dermatitis and intolerant of, or dependent on, topical corticosteroids.

TL;DR: There is a need for alternative treatments for atopic dermatitis of the face and neck as long‐term use of topical corticosteroids (TCS) is associated with skin atrophy and telangiectasia and some patients develop allergy, intolerance or other side‐effects.
References
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Book

The design and analysis of clinical experiments

TL;DR: The Parallel Groups Design as mentioned in this paper is a special case of the Parallel Groups Study, and it is used to control for prognostic variables in linear regression analysis of linear regressions of linear models.
Journal Article

Diagnostic features of atopic dermatitis

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Severe psoriasis--oral therapy with a new retinoid.

T. Fredriksson, +1 more
- 01 Jan 1978 - 
TL;DR: Ro 10--9359 proved to be an extremely potent antipsoriatic drug and a more than 90% reduction of psoriatic lesions could be seen in 10 patients out of 20 after 4-8 weeks of treatment.
Journal ArticleDOI

Large sample standard errors of kappa and weighted kappa.

TL;DR: The statistics kappa and weighted kappa (Cohen, 1960) were introduced to provide coefficients of agreement between two raters for nominal scales as discussed by the authors, and they were used to provide a measure of the relative seriousness of the different possible disagreements.
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