Journal ArticleDOI
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
Jon M. Hanifin,Thurston M,Thurston M,Omoto M,Omoto M,R. Cherill,R. Cherill,Susan J. Tofte,Graeber M,Graeber M +9 more
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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.Abstract:
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.read more
Citations
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Efficacy and Safety of Abrocitinib in Combination With Topical Therapy in Adolescents With Moderate-to-Severe Atopic Dermatitis: The JADE TEEN Randomized Clinical Trial.
Lawrence F. Eichenfield,Carsten Flohr,Robert Sidbury,Elaine C. Siegfried,Zsuzsanna Szalai,Ryszard Galus,Zhirong Yao,Hidetoshi Takahashi,Sébastien Barbarot,Claire Feeney,Fan Zhang,Marco DiBonaventura,Ricardo Rojo,Hernan Valdez,Gary Chan +14 more
TL;DR: In this paper, the authors investigated the efficacy and safety of oral abrocitinib plus topical therapy in adolescents with moderate-to-severe atopic dermatitis (AD) in a phase 3, randomized, double-blind, placebo-controlled study.
Journal ArticleDOI
Skin care interventions in infants for preventing eczema and food allergy
Maeve M Kelleher,Suzie Cro,Victoria Cornelius,Karin C. Lødrup Carlsen,Karin C. Lødrup Carlsen,Håvard Ove Skjerven,Eva Maria Rehbinder,Eva Maria Rehbinder,Adrian J. Lowe,Eishika Dissanayake,Naoki Shimojo,Kaori Yonezawa,Yukihiro Ohya,Kiwako Yamamoto-Hanada,Kumiko Morita,Emma Axon,Christian Surber,Christian Surber,Michael J. Cork,Alison Cooke,Lien Tran,Eleanor Van Vogt,Jochen Schmitt,Stephan Weidinger,Danielle McClanahan,Eric L. Simpson,Lelia Duley,Lisa M. Askie,Joanne R Chalmers,Hywel C Williams,Robert J. Boyle,Robert J. Boyle +31 more
TL;DR: In this paper, a systematic review of skin care interventions for early childhood immunoglobulin-E-mediated food allergy in infants is presented, where the authors identify features of study populations such as age, hereditary risk and adherence to interventions that are associated with the greatest treatment benefit or harm for both eczema and food allergy.
Journal ArticleDOI
A study of serum concentrations and dermal levels of NGF in atopic dermatitis and healthy subjects
Alexandru D.P. Papoiu,Hui Wang,Leigh A. Nattkemper,Hong Liang Tey,Yozo Ishiuji,Yiong Huak Chan,Martin Schmelz,Gil Yosipovitch +7 more
TL;DR: The fluctuations of NGF levels during the day suggest a complex modulation of this neurotrophin, potentially linked to stress or to an altered neurophysiological mechanism.
Book ChapterDOI
Clinical Development of Histamine H4 Receptor Antagonists
Robin L. Thurmond,Jennifer Venable,Brad M. Savall,David La,Sandra Snook,Paul J. Dunford,James P. Edwards +6 more
TL;DR: Clinical data to date suggests that H4R antagonists can be beneficial in treating atopic dermatitis and pruritus, despite the difficulty in finding ligands with all of the properties necessary for testing in the clinic.
Journal ArticleDOI
Consensus Guidelines for the Treatment of Atopic Dermatitis in Korea (Part II): Systemic Treatment.
Jung Eun Kim,Hyun Jeong Kim,Bark Lynn Lew,Kyung Ho Lee,Seung Phil Hong,Yong Hyun Jang,Kui Young Park,Seong Jun Seo,Jung Min Bae,Eung Ho Choi,Ki Beom Suhr,Seung-Chul Lee,Hyun Chang Ko,Young Lip Park,Sang Wook Son,Young Jun Seo,Yang Won Lee,Sang Hyun Cho,Chun Wook Park,Joo Young Roh +19 more
TL;DR: In this article, a database of references from relevant systematic reviews and guidelines regarding the systemic management of atopic dermatitis (AD) including antihistamines, antimicrobials, systemic immunomodulators, allergen-specific immunotherapy, phototherapy, adjunctive treatment, and complementary and alternative medicines was compiled.
References
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Book
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TL;DR: The Parallel Groups Design as mentioned in this paper is a special case of the Parallel Groups Study, and it is used to control for prognostic variables in linear regression analysis of linear regressions of linear models.
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Journal ArticleDOI
Severity Scoring of Atopic Dermatitis: The SCORAD Index
K.U. Schallreuter,Ch. Levenig,J. Berger,J. Umbert,R.K. Winkelmann,L. Wegener,O. Correia,Olivier Chosidow,P. Saiag,S. Bastuji-Garin,J. Revuz,Jean-Claude Roujeau,R. Situ,D.R. Inman,S.E.G. Fligiel,J. Varani,R.E. Schopf,J. Dobmeyer,T. Dobmeyer,B. Morsches,K. Holubar,G.E. Piérard,O. Bongard,H. Bounameaux,P. Corcuff,J.-L. Lévêque,J. Brasch,E. Christophers,G.T. Nahass,M. Sisto,S.A. Wagner,R.U. Peter,O. Adam,T. Ruzicka,J. McGrath,N.P. Burrows,R. Russell Jones,R.A.J. Eady,S. Veraldi,G. Rizzitelli,G. Lunghi,R. Cardone,R.M. Trüeb,G. Burg,F. Wantke,G. Fleischl,M. Götz,R. Jarisch,G. Tadini,E. Ermacora,S. Cambiaghi,A. Brusasco,R. Cavalli +52 more
TL;DR: Assessment methods for atopic dermatitis are not standardized, and therapeutic studies are difficult to interpret, so consensus on these methods is needed to obtain a consensus on them.
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Large sample standard errors of kappa and weighted kappa.
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