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The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis

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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.
Abstract
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.

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Citations
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Journal ArticleDOI

Improvement of atopic dermatitis with dupilumab occurs equally well across different anatomical regions: data from phase III clinical trials

TL;DR: Exposure to exposed areas such as the face, neck, and hands could be more vulnerable to environmental allergens and irritants and can be more refractory to topical therapies, which could influence AD severity on the face and neck.
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Benefits of mild cleansing: synthetic surfactant based (syndet) bars for patients with atopic dermatitis.

TL;DR: Syntet bar use reduced the severity of eczematous lesions, improved skin condition, and maintained hydration, indicating that syndet formulations are compatible with the therapy of AD.
Journal ArticleDOI

The fruits of Cudrania tricuspidata suppress development of atopic dermatitis in NC/Nga mice.

TL;DR: Findings indicate that C. tricuspidata inhibits the development of AD‐like skin lesions induced by repeated applications of D. farinae in sensitized NC/Nga by suppressing plasma concentrations of mTARC, histamine and IgE.
Journal ArticleDOI

Treatment outcomes of secondarily impetiginized pediatric atopic dermatitis lesions and the role of oral antibiotics

TL;DR: It is proposed that the inhibition of abnormal inflammation by the treatment regimen, resulting in the high levels of defensins, is involved in the improvement of AD and that systemic antibiotics do not appear to be necessary in secondary impetiginized AD.
References
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Book

The design and analysis of clinical experiments

TL;DR: The Parallel Groups Design as mentioned in this paper is a special case of the Parallel Groups Study, and it is used to control for prognostic variables in linear regression analysis of linear regressions of linear models.
Journal Article

Diagnostic features of atopic dermatitis

Journal ArticleDOI

Severe psoriasis--oral therapy with a new retinoid.

T. Fredriksson, +1 more
- 01 Jan 1978 - 
TL;DR: Ro 10--9359 proved to be an extremely potent antipsoriatic drug and a more than 90% reduction of psoriatic lesions could be seen in 10 patients out of 20 after 4-8 weeks of treatment.
Journal ArticleDOI

Large sample standard errors of kappa and weighted kappa.

TL;DR: The statistics kappa and weighted kappa (Cohen, 1960) were introduced to provide coefficients of agreement between two raters for nominal scales as discussed by the authors, and they were used to provide a measure of the relative seriousness of the different possible disagreements.
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