Journal ArticleDOI
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
Jon M. Hanifin,Thurston M,Thurston M,Omoto M,Omoto M,R. Cherill,R. Cherill,Susan J. Tofte,Graeber M,Graeber M +9 more
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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.Abstract:
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.read more
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Journal ArticleDOI
The reliability and validity of outcome measures for atopic dermatitis in patients with pigmented skin: A grey area.
Cathy Y. Zhao,Cathy Y. Zhao,Asri Wijayanti,M.C. Doria,M.C. Doria,Adam G. Harris,Adam G. Harris,Swaranjali V. Jain,K.N. Legaspi,K.N. Legaspi,Ncoza C. Dlova,Matthew Law,Dedee F. Murrell,Dedee F. Murrell +13 more
TL;DR: AD outcome measures have poor reliability and validity in highly pigmented patients, with variations in erythema perception being a contributor.
Journal ArticleDOI
Improvement of atopic dermatitis with dupilumab occurs equally well across different anatomical regions: data from phase III clinical trials
Andrew Blauvelt,David Rosmarin,T. Bieber,Eric L. Simpson,Jerry Bagel,Margitta Worm,Mette Deleuran,Norito Katoh,M. Kawashima,Brad Shumel,Zhen Chen,Ana B. Rossi,Thomas Hultsch,Marius Ardeleanu +13 more
TL;DR: Exposure to exposed areas such as the face, neck, and hands could be more vulnerable to environmental allergens and irritants and can be more refractory to topical therapies, which could influence AD severity on the face and neck.
Journal Article
Benefits of mild cleansing: synthetic surfactant based (syndet) bars for patients with atopic dermatitis.
Galina Solodkin,Umesh Chaudhari,Kumar Subramanyan,Anthony W Johnson,Xiaoyong Yan,Alice B. Gottlieb +5 more
TL;DR: Syntet bar use reduced the severity of eczematous lesions, improved skin condition, and maintained hydration, indicating that syndet formulations are compatible with the therapy of AD.
Journal ArticleDOI
The fruits of Cudrania tricuspidata suppress development of atopic dermatitis in NC/Nga mice.
Ho-Young Lee,Hyekyung Ha,Jun Kyung Lee,Chang-Seob Seo,Nam-Hun Lee,Da-Young Jung,Sang-Joon Park,Hyeun-Kyoo Shin +7 more
TL;DR: Findings indicate that C. tricuspidata inhibits the development of AD‐like skin lesions induced by repeated applications of D. farinae in sensitized NC/Nga by suppressing plasma concentrations of mTARC, histamine and IgE.
Journal ArticleDOI
Treatment outcomes of secondarily impetiginized pediatric atopic dermatitis lesions and the role of oral antibiotics
Jeffrey B. Travers,Amal Kozman,Yongxue Yao,Wenyu Ming M.D.,Weiguo Yao,Mathew J. Turner M.D.,Mark H. Kaplan,Nico Mousdicas,Anita N. Haggstrom,Chandan Saha +9 more
TL;DR: It is proposed that the inhibition of abnormal inflammation by the treatment regimen, resulting in the high levels of defensins, is involved in the improvement of AD and that systemic antibiotics do not appear to be necessary in secondary impetiginized AD.
References
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Severity Scoring of Atopic Dermatitis: The SCORAD Index
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