Journal ArticleDOI
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
Jon M. Hanifin,Thurston M,Thurston M,Omoto M,Omoto M,R. Cherill,R. Cherill,Susan J. Tofte,Graeber M,Graeber M +9 more
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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.Abstract:
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.read more
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Journal ArticleDOI
Dendritic cells produce inflammatory cytokines in response to bacterial products from Staphylococcus aureus-infected atopic dermatitis lesions
Timothy J Voorhees,Jihoon Chang,Yongxue Yao,Mark H. Kaplan,Cheong Hee Chang,Jeffrey B. Travers +5 more
TL;DR: Wash fluid derived from AD lesions induced cytokine production by murine bone marrow-derived DC, including IL-1β, IL-6, ΙL-10, and tumor necrosis factor-α, which support a role for DC in the worsening of AD inflammation due to secondary bacteria infections.
Journal ArticleDOI
A clinician's reference guide for the management of atopic dermatitis in Asians
Steven K.W. Chow,Chew Swee Seow,Maria Victoria Dizon,Kiran Godse,Henry Foong,Vicheth Chan,Tran Hau Khang,Leihong Xiang,Syarief Hidayat,M. Yulianto Listiawan,Danang Triwahyudi,Srie Prihianti Gondokaryono,Endang Sutedja,Inne Arline Diana,Oki Suwarsa,Hartati Purbo Dharmadji,Agnes Sri Siswati,Retno Danarti,Retno Widowati Soebaryo,Windy Keumala Budianti +19 more
TL;DR: The management of AD among Asians requires a holistic approach, integrating evidence-based treatments while considering accessibility and cultural acceptability.
Journal ArticleDOI
Addition of topical pimecrolimus to once-daily mid-potent steroid confers no short-term therapeutic benefit in the treatment of severe atopic dermatitis; a randomized controlled trial.
Jonathan M. Spergel,Mark Boguniewicz,Amy S. Paller,Adelaide A Hebert,P. R. Gallagher,C. McCormick,Anne Parneix-Spake,Thomas Hultsch +7 more
TL;DR: Combination therapy with pimecrolimus cream 1%, a topical calcineurin inhibitor (TCI), and fluticasone propionate cream 0·05% (FP), a mid‐potency topical corticosteroid, may have a synergistic effect for treatment of atopic dermatitis (AD) because their mechanism of action differs.
Journal ArticleDOI
The Traditional Chinese Medicine and Relevant Treatment for the Efficacy and Safety of Atopic Dermatitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
TL;DR: It is revealed that traditional Chinese medicines and related treatments did not show statistical differences in clinical effectiveness, SCORAD amelioration, and SSRI amelIORation for AD treatment compared with control group, however, EASI amalioration of traditional Chinese medicine and related treatment for AD was superior to control group.
Journal ArticleDOI
Sodium hypochlorite body wash in the management of Staphylococcus aureus-colonized moderate-to-severe atopic dermatitis in infants, children, and adolescents.
Sara Majewski,Tanya Bhattacharya,Manuela Loredana Asztalos,Benjamin R. Bohaty,Katherine C. Durham,Dennis P. West,Adelaide A. Hebert,Amy S. Paller +7 more
TL;DR: A cleansing body wash containing diluted sodium hypochlorite (0.006% NaOCl) was evaluated for management of moderate‐to‐severe Staphylococcus aureus–colonized, atopic dermatitis in children.
References
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Severity Scoring of Atopic Dermatitis: The SCORAD Index
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TL;DR: Assessment methods for atopic dermatitis are not standardized, and therapeutic studies are difficult to interpret, so consensus on these methods is needed to obtain a consensus on them.
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