Journal ArticleDOI
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
Jon M. Hanifin,Thurston M,Thurston M,Omoto M,Omoto M,R. Cherill,R. Cherill,Susan J. Tofte,Graeber M,Graeber M +9 more
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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.Abstract:
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.read more
Citations
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Journal ArticleDOI
Polygenic prediction of atopic dermatitis improves with atopic training and filaggrin factors.
Christopher H. Arehart,Michelle Daya,Monica Campbell,Meher Preethi Boorgula,Nicholas M. Rafaels,Sameer Chavan,Gloria David,Jon M. Hanifin,Mark K. Slifka,Richard L. Gallo,Tissa Hata,Lynda C. Schneider,Amy S. Paller,Amy S. Paller,Peck Y. Ong,Peck Y. Ong,Jonathan M. Spergel,Emma Guttman-Yassky,Donald Y.M. Leung,Lisa A. Beck,Christopher R. Gignoux,Rasika A. Mathias,Kathleen C. Barnes +22 more
TL;DR: In this article, a polygenic risk score (PRS) was constructed for 1619 European American individuals from the Atopic Dermatitis Research Network using an AD training dataset and an atopic training dataset including AD, childhood onset asthma, and general allergy.
Journal ArticleDOI
Efficacy and Safety of Soy Protein Based Formula in Atopic Dermatitis
Kkot Bora Yeom,Kyu Han Kim +1 more
TL;DR: It is suggested that SPF could be useful in decreasing the severity of AD without affecting infant growth status and could provide an adequate and safe alternative to hCMF in treating infants with AD and CMA during the first 12 to 24 months of their life.
Journal ArticleDOI
A mathematical model to identify optimal combinations of drug targets for dupilumab poor responders in atopic dermatitis.
TL;DR: In this paper, a model-based meta-analysis of recent clinical trials of atopic dermatitis (AD) biologics and developed a mathematical model that reproduces reported clinical efficacies for nine biological drugs by describing system-level AD pathogenesis.
Journal ArticleDOI
Base and Covariate Population Pharmacokinetic Analyses of Dupilumab Using Phase 3 Data.
Pavel Kovalenko,John D. Davis,Meng Li,Ronda Rippley,Marius Ardeleanu,Brad Shumel,Neil M.H. Graham,Gianluca Pirozzi,Mohamed A. Kamal,A. Thomas DiCioccio +9 more
TL;DR: While antidrug antibodies, albumin, race, body mass index, and Eczema Area and Severity Index score were statistically significant covariates, only body weight had a notable effect on central volume, explaining interindividual variability.
Journal ArticleDOI
Exploration of biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab: A study protocol.
Takeshi Nakahara,Kenji Izuhara,Daisuke Onozuka,Satoshi Nunomura,Risa Tamagawa-Mineoka,Koji Masuda,Susumu Ichiyama,Hidehisa Saeki,Y. Kabata,Riichiro Abe,Mamitaro Ohtsuki,Koji Kamiya,Tatsuro Okano,Tomomitsu Miyagaki,Yozo Ishiuji,Akihiko Asahina,Hiroshi Kawasaki,Keiji Tanese,Hiroshi Mitsui,Tatsuyoshi Kawamura,Takuya Takeichi,Masashi Akiyama,Emi Nishida,Akimichi Morita,Kyoko Tonomura,Yukinobu Nakagawa,Koji Sugawara,Chiharu Tateishi,Yoko Kataoka,Rai Fujimoto,Sakae Kaneko,Eishin Morita,Akio Tanaka,Michihiro Hide,Natsuko Aoki,Shigetoshi Sano,Haruna Matsuda-Hirose,Yutaka Hatano,Motoi Takenaka,Hiroyuki Murota,Norito Katoh,Masutaka Furue +41 more
TL;DR: The first clinical trial to explore the biomarkers, including potential proteomic markers, most strongly associated with improvement in EASI in patients with moderate-to-severe AD treated with dupilumab for 16 weeks (B-PAD study).
References
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Journal ArticleDOI
Severity Scoring of Atopic Dermatitis: The SCORAD Index
K.U. Schallreuter,Ch. Levenig,J. Berger,J. Umbert,R.K. Winkelmann,L. Wegener,O. Correia,Olivier Chosidow,P. Saiag,S. Bastuji-Garin,J. Revuz,Jean-Claude Roujeau,R. Situ,D.R. Inman,S.E.G. Fligiel,J. Varani,R.E. Schopf,J. Dobmeyer,T. Dobmeyer,B. Morsches,K. Holubar,G.E. Piérard,O. Bongard,H. Bounameaux,P. Corcuff,J.-L. Lévêque,J. Brasch,E. Christophers,G.T. Nahass,M. Sisto,S.A. Wagner,R.U. Peter,O. Adam,T. Ruzicka,J. McGrath,N.P. Burrows,R. Russell Jones,R.A.J. Eady,S. Veraldi,G. Rizzitelli,G. Lunghi,R. Cardone,R.M. Trüeb,G. Burg,F. Wantke,G. Fleischl,M. Götz,R. Jarisch,G. Tadini,E. Ermacora,S. Cambiaghi,A. Brusasco,R. Cavalli +52 more
TL;DR: Assessment methods for atopic dermatitis are not standardized, and therapeutic studies are difficult to interpret, so consensus on these methods is needed to obtain a consensus on them.
Journal ArticleDOI
Large sample standard errors of kappa and weighted kappa.
TL;DR: The statistics kappa and weighted kappa (Cohen, 1960) were introduced to provide coefficients of agreement between two raters for nominal scales as discussed by the authors, and they were used to provide a measure of the relative seriousness of the different possible disagreements.
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