Journal ArticleDOI
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
Jon M. Hanifin,Thurston M,Thurston M,Omoto M,Omoto M,R. Cherill,R. Cherill,Susan J. Tofte,Graeber M,Graeber M +9 more
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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.Abstract:
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.read more
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A statistical model to predict the reduction of lichenification in atopic dermatitis
TL;DR: A model in which the lichenification score drops off linearly with the square root of time is developed, which shows that fluticasone propionate can improve moderate to severe Lichenification in a relative short period of time.
Journal ArticleDOI
Comparison of real-world treatment outcomes of systemic immunomodulating therapy in atopic dermatitis patients with dark and light skin types
A.L. Bosma,Wouter Ouwerkerk,Madeline J. Heidema,David Prieto-Merino,Michael R. Ardern-Jones,P.E. Beattie,Sara J. Brown,John R. Ingram,Alan D. Irvine,Graham S. Ogg,Prakash Patel,Nick J. Reynolds,R. M. Ross Hearn,Mandy Wan,Richard B. Warren,R T Woolf,Ariënna M Hyseni,L. Gerbens,Ph.I. Spuls,Carsten Flohr,M.A. Middelkamp‐Hup +20 more
TL;DR: In an observational prospective cohort study, pooling data from the Dutch TREAT (TREATment of ATopic eczema) NL (treatregister.nl) and UK-Irish A-STAR registries, data on morphological phenotypes and treatment outcomes were investigated as discussed by the authors .
Journal ArticleDOI
Evaluation of standard treatments for managing adult Japanese patients with inadequately controlled moderate‐to‐severe atopic dermatitis: Two‐year data from the ADDRESS‐J disease registry
Norito Katoh,Hidehisa Saeki,Yoko Kataoka,Takafumi Etoh,Satoshi Teramukai,Hiroki Takagi,Hiroyuki Fujita,Marius Ardeleanu,E. Rizova,Kazuhiko Arima +9 more
TL;DR: It was showed that some patients with moderate or severe AD respond to conventional therapies, while others do not, and for those with inadequately controlled moderate‐to‐severe AD, the newly emerged systemic agents, such as biologics, may provide a potential strategy for long‐term disease management.
Journal ArticleDOI
Modulation of the immune response by infection with Cryptosporidium spp. in children with allergic diseases.
Janeth Oliva Guangorena-Gómez,Aurora Maravilla-Domínguez,Guadalupe García-Arenas,Maribel Cervantes‐Flores,Rocío Meza-Velázquez,Mario Alberto Rivera-Guillén,Leonor C. Acosta-Saavedra,Raquel C. Goytia-Acevedo +7 more
TL;DR: The first description of the modulation of the IR in children with allergic diseases in the setting of natural Cryptosporidium infection is described, suggesting the involvement of CD4+ cells producing IL‐4 and IFN‐γ in the IR to Cryptospora in naturally infected children.
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