Journal ArticleDOI
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
Jon M. Hanifin,Thurston M,Thurston M,Omoto M,Omoto M,R. Cherill,R. Cherill,Susan J. Tofte,Graeber M,Graeber M +9 more
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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.Abstract:
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.read more
Citations
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Leflunomide as a novel treatment option in severe atopic dermatitis.
TL;DR: Leflunomide is a pyrimidine de novo synthesis‐inhibiting immunosuppressant exhibiting an extremely long in vivo half life of its active metabolite.
Journal ArticleDOI
High prevalence of methicillin resistance and PVL genes among Staphylococcus aureus isolates from the nares and skin lesions of pediatric patients with atopic dermatitis.
Fernanda Sampaio Cavalcante,Eliane de Dios Abad,Y. C. Lyra,Simone Saintive,Márcia Gonçalves Ribeiro,Dennis de Carvalho Ferreira,K. R. N. dos Santos +6 more
TL;DR: There was a high prevalence of MRSA and PVL genes among the isolates recovered in this study, and these findings can help clinicians improve the therapies and strategies for the management of pediatric patients with AD.
Journal ArticleDOI
Atopic dermo-respiratory syndrome is a correlate of eczema herpeticum.
TL;DR: This work has shown that atopic dermo‐respiratory syndrome is a correlate of eczema herpeticum, and further studies are needed to establish a cause-and-effect relationship.
Journal ArticleDOI
Overview of efficacy and safety of tacrolimus ointment in patients with atopic dermatitis in Asia and other areas
TL;DR: Assessment of the efficacy and safety of tacrolimus ointment in a large population of patients with atopic dermatitis by pooling data from individual Asian studies to compare the results of this study with those in the United States, Europe, and Japan.
Journal ArticleDOI
A pilot study showing pulsed-dye laser treatment improves localized areas of chronic atopic dermatitis.
TL;DR: Eczematous skin changes overlying port‐wine stains have been reported to improve with pulsed‐dye laser treatment but PDL has not as yet been evaluated for the treatment of atopic dermatitis (AD; eczema).
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Severity Scoring of Atopic Dermatitis: The SCORAD Index
K.U. Schallreuter,Ch. Levenig,J. Berger,J. Umbert,R.K. Winkelmann,L. Wegener,O. Correia,Olivier Chosidow,P. Saiag,S. Bastuji-Garin,J. Revuz,Jean-Claude Roujeau,R. Situ,D.R. Inman,S.E.G. Fligiel,J. Varani,R.E. Schopf,J. Dobmeyer,T. Dobmeyer,B. Morsches,K. Holubar,G.E. Piérard,O. Bongard,H. Bounameaux,P. Corcuff,J.-L. Lévêque,J. Brasch,E. Christophers,G.T. Nahass,M. Sisto,S.A. Wagner,R.U. Peter,O. Adam,T. Ruzicka,J. McGrath,N.P. Burrows,R. Russell Jones,R.A.J. Eady,S. Veraldi,G. Rizzitelli,G. Lunghi,R. Cardone,R.M. Trüeb,G. Burg,F. Wantke,G. Fleischl,M. Götz,R. Jarisch,G. Tadini,E. Ermacora,S. Cambiaghi,A. Brusasco,R. Cavalli +52 more
TL;DR: Assessment methods for atopic dermatitis are not standardized, and therapeutic studies are difficult to interpret, so consensus on these methods is needed to obtain a consensus on them.
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