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Journal ArticleDOI

The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis

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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.
Abstract
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.

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A mathematical model to identify optimal combinations of drug targets for dupilumab poor responders in atopic dermatitis

TL;DR: In this paper, a model-based meta-analysis of recent clinical trials of atopic dermatitis (AD) biologics and developed a mathematical model that reproduces reported clinical efficacies for nine biological drugs (dupilumab, lebrikizumab and tralokinumab) by describing systems-level AD pathogenesis.
Book ChapterDOI

Advances in Assessing the Severity of Atopic Dermatitis

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Calcineurin inhibitors in the treatment of allergic dermatitis Inibidores de calcineurina no tratamento das dermatoses alØrgicas

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Journal ArticleDOI

General and Skin-Specific Health-Related Quality of Life in Patients With Atopic Dermatitis Before and During the COVID-19 Pandemic

TL;DR: In this article , the authors compared health-related quality of life (HRQoL) in patients with atopic dermatitis (AD) during the COVID-19 pandemic.
References
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Book

The design and analysis of clinical experiments

TL;DR: The Parallel Groups Design as mentioned in this paper is a special case of the Parallel Groups Study, and it is used to control for prognostic variables in linear regression analysis of linear regressions of linear models.
Journal Article

Diagnostic features of atopic dermatitis

Journal ArticleDOI

Severe psoriasis--oral therapy with a new retinoid.

T. Fredriksson, +1 more
- 01 Jan 1978 - 
TL;DR: Ro 10--9359 proved to be an extremely potent antipsoriatic drug and a more than 90% reduction of psoriatic lesions could be seen in 10 patients out of 20 after 4-8 weeks of treatment.
Journal ArticleDOI

Large sample standard errors of kappa and weighted kappa.

TL;DR: The statistics kappa and weighted kappa (Cohen, 1960) were introduced to provide coefficients of agreement between two raters for nominal scales as discussed by the authors, and they were used to provide a measure of the relative seriousness of the different possible disagreements.
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