Journal ArticleDOI
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
Jon M. Hanifin,Thurston M,Thurston M,Omoto M,Omoto M,R. Cherill,R. Cherill,Susan J. Tofte,Graeber M,Graeber M +9 more
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In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.Abstract:
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.read more
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Efficacy and safety of methylprednisolone aceponate ointment 0.1% compared to tacrolimus 0.03% in children and adolescents with an acute flare of severe atopic dermatitis
T. Bieber,K. Vick,Regina Fölster-Holst,A. Belloni-Fortina,G. Städtler,Margitta Worm,F. Arcangeli +6 more
TL;DR: This study compared efficacy and safety of 0.1% methylprednisolone aceponate (MPA) ointment with 0.03% tacrolimus ointments for 3 weeks in children and adolescents with severe to very severe flare of AD.
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Effectiveness of a multidisciplinary itch-coping training programme in adults with atopic dermatitis.
Andrea W M Evers,P. Duller,Elke M G J de Jong,M.E. Otero,Christianne M. Verhaak,Pieter G. M. Van Der Valk,Peter C.M. van de Kerkhof,Floris W. Kraaimaat +7 more
TL;DR: The brief multidisciplinary itch-coping programme in adults with atopic dermatitis considerably reduced itch-scratching patterns, improved their skin status and reduced the use of dermatological care, both in the short and longer term.
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Severe chronic allergic (and related) diseases: a uniform approach--a MeDALL--GA2LEN--ARIA position paper.
Jean Bousquet,Josep M. Antó,Pascal Demoly,Holger J. Schünemann,Alkis Togias,Mübeccel Akdis,Charles Auffray,Claus Bachert,T. Bieber,Philippe-Jean Bousquet,K-H. Carlsen,Thomas B. Casale,Alvaro A. Cruz,Thomas Keil,K. C. Lødrup Carlsen,Marcus Maurer,K. Ohta,Nikolaos G. Papadopoulos,M. Roman Rodriguez,B. Samolinski,Ioana Agache,A. Andrianarisoa,C. S. Ang,I. Annesi-Maesano,Ferran Ballester,C. E. Baena-Cagnani,C. E. Baena-Cagnani,X. Basagana,E.D. Bateman,E.H.D. Bel,A. Bedbrook,Bianca Beghe,M. Beji,A. Ben Kheder,Marta Benet,K. S. Bennoor,K. C. Bergmann,F. Berrissoul,C. Bindslev Jensen,Eugene R. Bleecker,Sergio Bonini,A. L. Boner,L.-P. Boulet,Christopher E. Brightling,Jan Brozek,Andrew Bush,William W. Busse,Paulo Augusto Moreira Camargos,G.W. Canonica,W. Carr,Alfredo Cesario,Y. Z. Chen,Anca-Mirela Chiriac,D. J. Costa,L. Cox,Adnan Custovic,Ronald Dahl,Ulf Darsow,T. Didi,William K. Dolen,H. Douagui,Ruta Dubakiene,A. El-Meziane,João Fonseca,W. J. Fokkens,Eleni Fthenou,Amiran Gamkrelidze,Judith Garcia-Aymerich,R. Gerth van Wijk,Elena Gimeno-Santos,Stefano Guerra,Tari Haahtela,H. Haddad,P W Hellings,B. Hellquist-Dahl,Cynthia Hohmann,Peter H. Howarth,J. O. B. Hourihane,Marc Humbert,Bénédicte Jacquemin,J. Just,O. Kalayci,Michael A. Kaliner,F. Kauffmann,Marjan Kerkhof,G. Khayat,B. Koffi N'Goran,Manolis Kogevinas,Gerard H. Koppelman,Marek L. Kowalski,Inger Kull,Piotr Kuna,Désirée Larenas,Iris Lavi,L. T. Le,Phil Lieberman,Brian J. Lipworth,Bassam Mahboub,Mika J. Mäkelä,F. Martin,Fernando D. Martinez,Gailen D. Marshall,A. Mazon,E. Melen,Eli O. Meltzer,F. Mihaltan,Yousser Mohammad,A. Mohammadi,Isabelle Momas,M. Morais-Almeida,J Mullol,Antonella Muraro,Robert M. Naclerio,S. Nafti,L. Namazova-Baranova,Martijn C. Nawijn,T. D. Nyembue,Sam Oddie,Robyn E O'Hehir,Y. Okamoto,M. P. Orru,Cevdet Ozdemir,G. S. Ouedraogo,S. Palkonen,P. Panzner,G. Passalacqua,Ruby Pawankar,B. Pigearias,I. Pin,Mariona Pinart,Christophe Pison,Todor A. Popov,Daniela Porta,Dirkje S. Postma,David Price,Klaus F. Rabe,J. Ratomaharo,Sakari Reitamo,D. Rezagui,J. Ring,Richard G. Roberts,Josep Roca,Barbara Rogala,Antonino Romano,J Rosado-Pinto,Dermot Ryan,Mario Sánchez-Borges,G. K. Scadding,Aziz Sheikh,F. E. R. Simons,Valérie Siroux,Valérie Siroux,Peter Schmid-Grendelmeier,Henriette A. Smit,Talant Sooronbaev,Renato T. Stein,Peter J. Sterk,Jordi Sunyer,Ingrid Terreehorst,Elina Toskala,Y. Tremblay,Rudolph Valenta,Dominique Valeyre,Olivier Vandenplas,C. van Weel,Maria Vassilaki,Raphaëlle Varraso,Giovanni Viegi,D. Y. Wang,Magnus Wickman,Dennis M. Williams,Stefan Wöhrl,John Wright,A. Yorgancioglu,Osman M. Yusuf,H. J. Zar,M. E. Zernotti,Mihaela Zidarn,Nanshan Zhong,T. Zuberbier +179 more
TL;DR: In this article, the authors generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis and chronic urticaria and atopic dermatitis) in order to have a unified definition of severity, control and risk, usable in most situations.
Journal ArticleDOI
Etanercept is minimally effective in 2 children with atopic dermatitis.
Journal ArticleDOI
Consensus guidelines in diagnosis and treatment of atopic dermatitis.
TL;DR: Development of consensus guidelines on diagnosis and treatment of atopic dermatitis are discussed, and disease‐severity‐based guidelines of care proposed.
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Journal ArticleDOI
Severity Scoring of Atopic Dermatitis: The SCORAD Index
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TL;DR: Assessment methods for atopic dermatitis are not standardized, and therapeutic studies are difficult to interpret, so consensus on these methods is needed to obtain a consensus on them.
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