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Journal ArticleDOI

The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis

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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.
Abstract
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.

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Journal ArticleDOI

Grading of the severity of atopic dermatitis.

G Rajka, +1 more
TL;DR: A simple system for baseline grading the severity of atopic dermatitis in clinical work, which permits distinction between mild, moderate and severe atopic skin disease by means of a score summation using the rule of nine.
Journal ArticleDOI

A 12-week study of tacrolimus ointment for the treatment of atopic dermatitis in pediatric patients.

TL;DR: Both tacrolimus ointment concentrations (0.03% and 0.1%) were safe and significantly more effective than vehicle for the treatment of atopic dermatitis in children.
Journal ArticleDOI

Long-term safety and efficacy of tacrolimus ointment for the treatment of atopic dermatitis in children.

TL;DR: Tacrolimus ointment (0.1%) is safe and effective for long-term treatment of atopic dermatitis in children and was maintained with prolonged daily use.
Journal ArticleDOI

Tacrolimus ointment for the treatment of atopic dermatitis in adult patients: Part I, efficacy

TL;DR: Tacrolimus ointment-treated patients showed significantly greater improvement than vehicle- treated patients for all efficacy parameters evaluated, including the %BSA affected, the total score and individual scores for signs of atopic dermatitis, the patient's assessment of pruritus, and EASI score.
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