Journal ArticleDOI
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
Jon M. Hanifin,Thurston M,Thurston M,Omoto M,Omoto M,R. Cherill,R. Cherill,Susan J. Tofte,Graeber M,Graeber M +9 more
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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.Abstract:
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.read more
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Skin biomarkers predict development of atopic dermatitis in infancy
Maria Rasmussen Rinnov,Anne-Sofie Halling,Trine Gerner,Nina Haarup Ravn,Mette Hjorslev Knudgaard,Simon Trautner,Susanna M.I. Goorden,Karen Ghauharali-van der Vlugt,Femke S Stet,Lone Skov,Simon Francis Thomsen,Alexander Egeberg,A. L. Rosted,Troels Petersen,Ivone Jakasa,Christoph Riethmüller,Sanja Kezic,Jacob P. Thyssen +17 more
TL;DR: It was shown that levels and SB chain length were altered in infants who later developed AD, and that TARC/CCL17 levels were higher.
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Topical tacrolimus vs medium-dose ultraviolet A1 phototherapy in the treatment of atopic dermatitis - a preliminary study in relation to parameters of the epidermal barrier function and high-frequency ultrasonography.
TL;DR: The beneficial influence of both therapies on the course of moderate-severe AD was confirmed, with tacrolimus induced a greater reduction in TEWL, while phototherapy caused the reduction of subepidermal low echogenic band-SLEB within sites affected with pathological lesions.
Journal ArticleDOI
Expression patterns of atopic eczema and respiratory illnesses in a high-risk birth cohort
Anne Marie Singh,Michael D. Evans,Ronald E. Gangnon,Kathy A. Roberg,Christopher J. Tisler,Douglas F. DaSilva,Tressa Pappas,L.E.P. Salazar,Elizabeth L. Anderson,James E. Gern,Robert F. Lemanske,Christine M. Seroogy +11 more
TL;DR: Increased severity of respiratory illnesses, RSV wheezing and early allergic sensitization were significant risk factors for atopic eczema disease persistence in children representing a distinct phenotype of AE.
Journal ArticleDOI
Treatment of Atopic Dermatitis with Baricitinib: First Real-life Experience
TL;DR: In this paper , the authors present a short communication (Short communication) between the authors and the authors of this paper. But this short communication is missing (short communication) in short communication.
Journal ArticleDOI
The efficacy and safety of upadacitinib treatment for moderate to severe atopic dermatitis in real‐world practice in Japan
TL;DR: Upadacitinib plus topical corticosteroids for patients with AD in the real-world practice was well tolerated and gave therapeutic effects comparable with those in previous clinical trials.
References
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Journal ArticleDOI
Severity Scoring of Atopic Dermatitis: The SCORAD Index
K.U. Schallreuter,Ch. Levenig,J. Berger,J. Umbert,R.K. Winkelmann,L. Wegener,O. Correia,Olivier Chosidow,P. Saiag,S. Bastuji-Garin,J. Revuz,Jean-Claude Roujeau,R. Situ,D.R. Inman,S.E.G. Fligiel,J. Varani,R.E. Schopf,J. Dobmeyer,T. Dobmeyer,B. Morsches,K. Holubar,G.E. Piérard,O. Bongard,H. Bounameaux,P. Corcuff,J.-L. Lévêque,J. Brasch,E. Christophers,G.T. Nahass,M. Sisto,S.A. Wagner,R.U. Peter,O. Adam,T. Ruzicka,J. McGrath,N.P. Burrows,R. Russell Jones,R.A.J. Eady,S. Veraldi,G. Rizzitelli,G. Lunghi,R. Cardone,R.M. Trüeb,G. Burg,F. Wantke,G. Fleischl,M. Götz,R. Jarisch,G. Tadini,E. Ermacora,S. Cambiaghi,A. Brusasco,R. Cavalli +52 more
TL;DR: Assessment methods for atopic dermatitis are not standardized, and therapeutic studies are difficult to interpret, so consensus on these methods is needed to obtain a consensus on them.
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