Journal ArticleDOI
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
Jon M. Hanifin,Thurston M,Thurston M,Omoto M,Omoto M,R. Cherill,R. Cherill,Susan J. Tofte,Graeber M,Graeber M +9 more
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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.Abstract:
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.read more
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Topical anti-inflammatory treatments for eczema: network meta-analysis
Lloyd Steele,Beth Stuart,Emma Axon,Stephanie J. Lax,Jane Ellen Harvey,Amanda Roberts,Miriam Santer,Hywel C Williams,Aaron M. Drucker,Robert J. Boyle +9 more
TL;DR: In this article , the authors compared the efficacy and safety of topical anti-inflammatory treatments for reducing eczema symptoms or signs or improving the quality of life in children and adults.
Journal ArticleDOI
Prescribing for children with atopic eczema in primary care
TL;DR: Advice on patient assessment; developing a patient-centred plan of care; the topical products most effective for managing the condition; how optimal adherence to the treatment may be achieved; and when referral to services in secondary care is appropriate are given.
Journal ArticleDOI
Translating the Investigator's Static Global Assessment to the Eczema Area and Severity Index in Studies of Crisaborole for Atopic Dermatitis.
Jacob P. Thyssen,Chuanbo Zang,Maureen P Neary,Andrew G. Bushmakin,Joseph C. Cappelleri,Amy Cha,Christopher Russo,Thomas A. Luger +7 more
TL;DR: In this paper, the authors used the Investigator's Static Global Assessment (ISGA) scale to assess atopic dermatitis (AD) severity in patients with mild-to-moderate AD.
Journal ArticleDOI
Efficacy of a 3% Kānuka oil cream for the treatment of moderate-to-severe eczema: A single blind randomised vehicle-controlled trial
Nicholas Shortt,Alexander D. Martin,Kyley Kerse,Gabrielle A. Shortt,Iva Vakalalabure,Luke Barker,Joseph Singer,Bianca Black,Angela Liu,Allie Eathorne,Mark Weatherall,Marius Rademaker,Mike Armour,Richard Beasley,Alex Semprini +14 more
TL;DR: In this paper , the authors investigated the efficacy and safety of a 3% kānuka oil (KO) cream compared to vehicle control (VC) for the topical treatment of eczema.
The Efficacy Of Using Tacrolimus Ointment On Children With Atopic Dermatitis
TL;DR: Tacrolimus ointment was significantly more effective than the vehicle control for treatment of atopic dermatitis and is effective to use on children with atopy dermatitis.
References
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Severity Scoring of Atopic Dermatitis: The SCORAD Index
K.U. Schallreuter,Ch. Levenig,J. Berger,J. Umbert,R.K. Winkelmann,L. Wegener,O. Correia,Olivier Chosidow,P. Saiag,S. Bastuji-Garin,J. Revuz,Jean-Claude Roujeau,R. Situ,D.R. Inman,S.E.G. Fligiel,J. Varani,R.E. Schopf,J. Dobmeyer,T. Dobmeyer,B. Morsches,K. Holubar,G.E. Piérard,O. Bongard,H. Bounameaux,P. Corcuff,J.-L. Lévêque,J. Brasch,E. Christophers,G.T. Nahass,M. Sisto,S.A. Wagner,R.U. Peter,O. Adam,T. Ruzicka,J. McGrath,N.P. Burrows,R. Russell Jones,R.A.J. Eady,S. Veraldi,G. Rizzitelli,G. Lunghi,R. Cardone,R.M. Trüeb,G. Burg,F. Wantke,G. Fleischl,M. Götz,R. Jarisch,G. Tadini,E. Ermacora,S. Cambiaghi,A. Brusasco,R. Cavalli +52 more
TL;DR: Assessment methods for atopic dermatitis are not standardized, and therapeutic studies are difficult to interpret, so consensus on these methods is needed to obtain a consensus on them.
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