Journal ArticleDOI
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
Jon M. Hanifin,Thurston M,Thurston M,Omoto M,Omoto M,R. Cherill,R. Cherill,Susan J. Tofte,Graeber M,Graeber M +9 more
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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.Abstract:
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.read more
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Journal ArticleDOI
Guidelines of care for atopic dermatitis
Jon M. Hanifin,Kevin D. Cooper,Vincent C. Ho,Sewon Kang,Bernice R Krafchik,David J. Margolis,Lawrence A Schachner,Robert Sidbury,Susan E Whitmore,Carol K. Sieck,Abby S. Van Voorhees +10 more
TL;DR: The ultimate judgment regarding the propriety of any specific therapy must be made by the physician and the patient in light of all the circumstances presented by the individual patient.
Journal ArticleDOI
Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis.
Jennifer D. Hamilton,Mayte Suárez-Fariñas,Nikhil Dhingra,Irma Cardinale,Xuan Li,Ana Kostic,Jeffrey Ming,Allen Radin,James G. Krueger,Neil M.H. Graham,George D. Yancopoulos,Gianluca Pirozzi,Emma Guttman-Yassky,Emma Guttman-Yassky +13 more
TL;DR: This is the first report showing rapid improvement of the AD molecular signature with targeted anti-IL-4 receptor α therapy, and data suggest that IL-4 and IL-13 drive a complex, TH2-centered inflammatory axis in patients with AD.
Journal ArticleDOI
Efficacy and Safety of Pimecrolimus Cream in the Long-Term Management of Atopic Dermatitis in Children
Ulrich Wahn,Jan D. Bos,Mark Goodfield,Ruggero Caputo,Kim A. Papp,Ahmed Manjra,Attila Dobozy,Carle Paul,Stephen Molloy,Thomas Hultsch,Michael Graeber,Robert Cherill,Yves de Prost +12 more
TL;DR: Patients in the pimecrolimus group experienced significantly fewer AD flares than those in the control group, according to the primary efficacy analysis on ranked flares of AD (Van Elteren test).
Journal ArticleDOI
What are the best outcome measurements for atopic eczema? A systematic review
TL;DR: There are too many published outcome measures for AE, most of which have not been tested properly or perform adequately when tested, and their continued use hampers scientific communication.
Journal ArticleDOI
Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children
Susan V. Lynch,Robert A. Wood,Homer A. Boushey,Leonard B. Bacharier,Gordon R. Bloomberg,Meyer Kattan,George T. O'Connor,Megan Sandel,Agustin Calatroni,Elizabeth C. Matsui,Christine Cole Johnson,Henry Lynn,Cynthia M. Visness,Katy F. Jaffee,Peter J. Gergen,Diane R. Gold,Rosalind J. Wright,Kei E. Fujimura,Marcus Rauch,William W. Busse,James E. Gern +20 more
TL;DR: In inner-city environments children with the highest exposure to specific allergens and bacteria during their first year were least likely to have recurrent wheeze and allergic sensitization, and concomitant exposure to high levels of certain Allergen and bacteria in early life might be beneficial.
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TL;DR: Assessment methods for atopic dermatitis are not standardized, and therapeutic studies are difficult to interpret, so consensus on these methods is needed to obtain a consensus on them.
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