Journal ArticleDOI
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
Jon M. Hanifin,Thurston M,Thurston M,Omoto M,Omoto M,R. Cherill,R. Cherill,Susan J. Tofte,Graeber M,Graeber M +9 more
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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.Abstract:
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.read more
Citations
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Journal ArticleDOI
Exploring the Relationship Between Dermatology Life Quality Index, Eczema Area and Severity Index, and Sleep Numerical Rating Scale and Pruritus Numerical Rating Scale in Patients with Atopic Dermatitis Treated with Dupilumab.
Filomena Russo,Vittoria Cioppa,Alessandra Cartocci,Ernesto De Piano,Paolo Taddeucci,Laura Lazzeri,Francesco Santi,Pietro Rubegni +7 more
TL;DR: In this article , the relationship between severity and QoL-related scores in patients with moderate-to-severe AD treated with dupilumab was analyzed. And the results showed that the reduction in the impact of atopic dermatitis (AD) for AD patients in the first months of therapy was correlated more with the control of pruritus than with the disappearance of skin lesions.
Patent
Traitement de la dermatite atopique par de l'extrait d'indigo naturel ou par de l'extrait de plante produisant de l'indigo
TL;DR: In this article, a composition pharmaceutique ou cosmetique comprenant de l'extrait d'indigo naturel ou de l''extrait de plante produisant of l''indigo, for traitement de la dermatite atopique et de toute forme d'eczema, ainsi qu'une methode de traitement of the dermatite topique consistant a administrer une quantite therapeutiquement efficace d'un extrait d'' indigo nature l ou d''
Journal ArticleDOI
Clinicopathological Differences between Acquired Reactive Perforating Collagenosis and Prurigo Nodularis
Miho Kawamura,Madoka Inoue,Kanako Matsuyama,Yoko Mizutani,En Shu,Tatsuhiko Miyazaki,Mariko Seishima +6 more
TL;DR: It is suggested that the addition of emollients can increase the efficacy of treatments for ARPC, and inflammation mediated by neutrophils and M2 macrophages may be involved in the formation of ARPC lesions, as against PN lesions mediated by epidermal changes such as spongiosis.
Ultra-pure soft water improves skin barrier function in children with atopic dermatitis: A randomized, double-blind, placebo-controlled, crossover pilot study
Mitsuha Hayashi,Tsuguhisa Nakayama,Tomomitsu Hirota,Hidehisa Saeki,Yoshimasa Nobeyama,Toshihiro Ito,Yoshinori Umezawa,Osamu Fukuchi,Koichi Yanaba,Sota Kikuchi,Hidemi Nakagawa,Y. Tsunemi,Sayaka Shibata,Shinichi Sato,Yayoi Tada,Akihiko Miyatake,Shigeharu Fujieda,Mayumi Tamari +17 more
TL;DR: Li et al. as discussed by the authors found that rare pathogenic variants in IL36RN underlie a spectrum of psoriasis-associated pustular phenotypes, and they proposed a method to identify these variants.
References
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Journal ArticleDOI
Severity Scoring of Atopic Dermatitis: The SCORAD Index
K.U. Schallreuter,Ch. Levenig,J. Berger,J. Umbert,R.K. Winkelmann,L. Wegener,O. Correia,Olivier Chosidow,P. Saiag,S. Bastuji-Garin,J. Revuz,Jean-Claude Roujeau,R. Situ,D.R. Inman,S.E.G. Fligiel,J. Varani,R.E. Schopf,J. Dobmeyer,T. Dobmeyer,B. Morsches,K. Holubar,G.E. Piérard,O. Bongard,H. Bounameaux,P. Corcuff,J.-L. Lévêque,J. Brasch,E. Christophers,G.T. Nahass,M. Sisto,S.A. Wagner,R.U. Peter,O. Adam,T. Ruzicka,J. McGrath,N.P. Burrows,R. Russell Jones,R.A.J. Eady,S. Veraldi,G. Rizzitelli,G. Lunghi,R. Cardone,R.M. Trüeb,G. Burg,F. Wantke,G. Fleischl,M. Götz,R. Jarisch,G. Tadini,E. Ermacora,S. Cambiaghi,A. Brusasco,R. Cavalli +52 more
TL;DR: Assessment methods for atopic dermatitis are not standardized, and therapeutic studies are difficult to interpret, so consensus on these methods is needed to obtain a consensus on them.
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Large sample standard errors of kappa and weighted kappa.
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