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The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis

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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.
Abstract
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.

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Citations
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Journal ArticleDOI

Exploring the Relationship Between Dermatology Life Quality Index, Eczema Area and Severity Index, and Sleep Numerical Rating Scale and Pruritus Numerical Rating Scale in Patients with Atopic Dermatitis Treated with Dupilumab.

TL;DR: In this article , the relationship between severity and QoL-related scores in patients with moderate-to-severe AD treated with dupilumab was analyzed. And the results showed that the reduction in the impact of atopic dermatitis (AD) for AD patients in the first months of therapy was correlated more with the control of pruritus than with the disappearance of skin lesions.
Patent

Traitement de la dermatite atopique par de l'extrait d'indigo naturel ou par de l'extrait de plante produisant de l'indigo

TL;DR: In this article, a composition pharmaceutique ou cosmetique comprenant de l'extrait d'indigo naturel ou de l''extrait de plante produisant of l''indigo, for traitement de la dermatite atopique et de toute forme d'eczema, ainsi qu'une methode de traitement of the dermatite topique consistant a administrer une quantite therapeutiquement efficace d'un extrait d'' indigo nature l ou d''
Journal ArticleDOI

Clinicopathological Differences between Acquired Reactive Perforating Collagenosis and Prurigo Nodularis

TL;DR: It is suggested that the addition of emollients can increase the efficacy of treatments for ARPC, and inflammation mediated by neutrophils and M2 macrophages may be involved in the formation of ARPC lesions, as against PN lesions mediated by epidermal changes such as spongiosis.
References
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Book

The design and analysis of clinical experiments

TL;DR: The Parallel Groups Design as mentioned in this paper is a special case of the Parallel Groups Study, and it is used to control for prognostic variables in linear regression analysis of linear regressions of linear models.
Journal Article

Diagnostic features of atopic dermatitis

Journal ArticleDOI

Severe psoriasis--oral therapy with a new retinoid.

T. Fredriksson, +1 more
- 01 Jan 1978 - 
TL;DR: Ro 10--9359 proved to be an extremely potent antipsoriatic drug and a more than 90% reduction of psoriatic lesions could be seen in 10 patients out of 20 after 4-8 weeks of treatment.
Journal ArticleDOI

Large sample standard errors of kappa and weighted kappa.

TL;DR: The statistics kappa and weighted kappa (Cohen, 1960) were introduced to provide coefficients of agreement between two raters for nominal scales as discussed by the authors, and they were used to provide a measure of the relative seriousness of the different possible disagreements.
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