Journal ArticleDOI
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
Jon M. Hanifin,Thurston M,Thurston M,Omoto M,Omoto M,R. Cherill,R. Cherill,Susan J. Tofte,Graeber M,Graeber M +9 more
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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.Abstract:
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.read more
Citations
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Journal ArticleDOI
Increased serum levels of interleukin 33 in patients with atopic dermatitis
TL;DR: The results suggest that IL-33 released from mechanically injured or barrier-disrupted skin may increase inflammation in AD and be correlated with the disease severity of AD.
Journal ArticleDOI
Topical tacrolimus for atopic dermatitis.
Jade Cury Martins,Ciro Martins,Valeria Aoki,Aécio Flávio Teixeira de Góis,Henrique A Ishii,Edina Mariko Koga da Silva +5 more
TL;DR: The efficacy and safety of topical tacrolimus for moderate and severe atopic dermatitis compared with other active treatments and assessment of improvement of the disease by validated or objective measures are assessed.
Journal ArticleDOI
Tacrolimus ointment is more effective than pimecrolimus cream with a similar safety profile in the treatment of atopic dermatitis: results from 3 randomized, comparative studies.
Amy S. Paller,Mark Lebwohl,Alan B. Fleischer,Richard J. Antaya,Richard G. Langley,Robert S. Kirsner,Robin R. Blum,M. Joyce Rico,Eileen Jaracz,Andrew W. Crowe,Gregory J. Linowski +10 more
TL;DR: Tacrolimus ointment is more effective and has a faster onset of action than pimecrolimus cream in adults and children with AD; their safety profiles are similar.
Journal ArticleDOI
Randomized trial of vitamin D supplementation for winter-related atopic dermatitis in children
Carlos A. Camargo,Davaasambuu Ganmaa,Davaasambuu Ganmaa,Robert Sidbury,Kh. Erdenedelger,N. Radnaakhand,B. Khandsuren +6 more
TL;DR: Vitamin D supplementation improved winter-related atopic dermatitis among Mongolian children, a population likely to have vitamin D deficiency in winter.
Journal ArticleDOI
Efficacy and safety of tacrolimus ointment treatment for up to 4 years in patients with atopic dermatitis.
Jon M. Hanifin,Amy S. Paller,Lawrence F. Eichenfield,Richard A.F. Clark,Neil J. Korman,Gerald D. Weinstein,Ivor Caro,Eileen Jaracz,M. Joyce Rico +8 more
TL;DR: Tacrolimus ointment therapy is a rapidly effective and safe treatment for the management of atopic dermatitis in pediatric and adult patients for up to 4 years as mentioned in this paper.
References
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TL;DR: The Parallel Groups Design as mentioned in this paper is a special case of the Parallel Groups Study, and it is used to control for prognostic variables in linear regression analysis of linear regressions of linear models.
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Journal ArticleDOI
Severity Scoring of Atopic Dermatitis: The SCORAD Index
K.U. Schallreuter,Ch. Levenig,J. Berger,J. Umbert,R.K. Winkelmann,L. Wegener,O. Correia,Olivier Chosidow,P. Saiag,S. Bastuji-Garin,J. Revuz,Jean-Claude Roujeau,R. Situ,D.R. Inman,S.E.G. Fligiel,J. Varani,R.E. Schopf,J. Dobmeyer,T. Dobmeyer,B. Morsches,K. Holubar,G.E. Piérard,O. Bongard,H. Bounameaux,P. Corcuff,J.-L. Lévêque,J. Brasch,E. Christophers,G.T. Nahass,M. Sisto,S.A. Wagner,R.U. Peter,O. Adam,T. Ruzicka,J. McGrath,N.P. Burrows,R. Russell Jones,R.A.J. Eady,S. Veraldi,G. Rizzitelli,G. Lunghi,R. Cardone,R.M. Trüeb,G. Burg,F. Wantke,G. Fleischl,M. Götz,R. Jarisch,G. Tadini,E. Ermacora,S. Cambiaghi,A. Brusasco,R. Cavalli +52 more
TL;DR: Assessment methods for atopic dermatitis are not standardized, and therapeutic studies are difficult to interpret, so consensus on these methods is needed to obtain a consensus on them.
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Large sample standard errors of kappa and weighted kappa.
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