Journal ArticleDOI
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
Jon M. Hanifin,Thurston M,Thurston M,Omoto M,Omoto M,R. Cherill,R. Cherill,Susan J. Tofte,Graeber M,Graeber M +9 more
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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.Abstract:
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.read more
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Systemic exposure, tolerability, and efficacy of pimecrolimus cream 1% in atopic dermatitis patients
B. R. Allen,M. Lakhanpaul,Andrew Morris,S Lateo,T. Davies,G Scott,M. Cardno,ME Ebelin,P. Burtin,TJ Stephenson +9 more
TL;DR: Three weeks treatment of children and infants with extensive atopic dermatitis, using pimecrolimus cream 1% twice daily, is well tolerated and results in minimal systemic exposure, at which no systemic effect is expected.
Journal ArticleDOI
The burden of atopic dermatitis in US adults: results from the 2013 National Health and Wellness Survey
TL;DR: The significant burden associated with AD relative to those without AD suggests an unmet need for more effective management strategies and there appears to be a need for further characterization of disease severity and its impact on HRQoL.
Journal ArticleDOI
A phase 2, randomized dose-finding study of tapinarof (GSK2894512 cream) for the treatment of atopic dermatitis.
Johnny Peppers,Amy S. Paller,Tomoko Maeda-Chubachi,Sterling Wu,Kevin Robbins,Kelly Gallagher,John E. Kraus +6 more
TL;DR: Tapinarof cream is efficacious and well tolerated in adolescent and adult patients with AD and the rate of treatment‐emergent adverse events was higher with tapinarof than with vehicle, and the events were mild to moderate in intensity.
Journal ArticleDOI
The Urban Environment and Childhood Asthma (URECA) birth cohort study: design, methods, and study population
James E. Gern,Cynthia M. Visness,Peter J. Gergen,Robert A. Wood,Gordon R. Bloomberg,George T. O'Connor,Meyer Kattan,Hugh A. Sampson,Frank R. Witter,Megan Sandel,Wayne G. Shreffler,Rosalind J. Wright,Samuel J. Arbes,William W. Busse +13 more
TL;DR: The primary hypothesis is that specific urban exposures in early life promote a unique pattern of immune development that increases the risk of recurrent wheezing and allergic sensitization in early childhood and of asthma by age 7 years.
Journal ArticleDOI
Update on Atopic Dermatitis: Diagnosis, Severity Assessment, and Treatment Selection.
TL;DR: An overview of AD is provided, including strategies for differential diagnosis and assessment of disease severity to guide treatment selection, and key clinical trials for crisaborole and dupilumab are reviewed, and other targeted treatments now in development are summarized.
References
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The design and analysis of clinical experiments
TL;DR: The Parallel Groups Design as mentioned in this paper is a special case of the Parallel Groups Study, and it is used to control for prognostic variables in linear regression analysis of linear regressions of linear models.
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Journal ArticleDOI
Severity Scoring of Atopic Dermatitis: The SCORAD Index
K.U. Schallreuter,Ch. Levenig,J. Berger,J. Umbert,R.K. Winkelmann,L. Wegener,O. Correia,Olivier Chosidow,P. Saiag,S. Bastuji-Garin,J. Revuz,Jean-Claude Roujeau,R. Situ,D.R. Inman,S.E.G. Fligiel,J. Varani,R.E. Schopf,J. Dobmeyer,T. Dobmeyer,B. Morsches,K. Holubar,G.E. Piérard,O. Bongard,H. Bounameaux,P. Corcuff,J.-L. Lévêque,J. Brasch,E. Christophers,G.T. Nahass,M. Sisto,S.A. Wagner,R.U. Peter,O. Adam,T. Ruzicka,J. McGrath,N.P. Burrows,R. Russell Jones,R.A.J. Eady,S. Veraldi,G. Rizzitelli,G. Lunghi,R. Cardone,R.M. Trüeb,G. Burg,F. Wantke,G. Fleischl,M. Götz,R. Jarisch,G. Tadini,E. Ermacora,S. Cambiaghi,A. Brusasco,R. Cavalli +52 more
TL;DR: Assessment methods for atopic dermatitis are not standardized, and therapeutic studies are difficult to interpret, so consensus on these methods is needed to obtain a consensus on them.
Journal ArticleDOI
Large sample standard errors of kappa and weighted kappa.
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