Journal ArticleDOI
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
Jon M. Hanifin,Thurston M,Thurston M,Omoto M,Omoto M,R. Cherill,R. Cherill,Susan J. Tofte,Graeber M,Graeber M +9 more
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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.Abstract:
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.read more
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Use of gram negative species to treat atopic dermatitis
Ian A. Myles,Sandip K. Datta +1 more
TL;DR: In this article, the pharmaceutical compositions are formulated for topical administration for treating atopic dermatitis using a purified viable gram negative bacteria and a pharmaceutically acceptable carrier, which includes a therapeutically effective amount of a distilled viable gramnegative bacteria and an acceptable carrier.
Journal ArticleDOI
Clinical effectiveness of amino acid formula in infants with severe atopic dermatitis and cow’s-milk protein allergy
Serhiy Nyankovskyy,Olena Nyankovska,Dmytro Dobryanskyy,Oleg Shadrin,Viktoria Klimenko,Marta Iatsula,Svetlana Nedelska,Oleksandr Ashcheulov,Hanna Haiduchyk,Olga Paholchuk +9 more
TL;DR: Feeding with AAF was associated with reliable reduction of severity not only of isolated skin but of combined skin and gastrointestinal manifestations of food allergy, and the formula was well tolerated by infants with severe AD.
Journal ArticleDOI
Роль генетических детерминант и нарушений в системном и местном иммунитете в этиологии и патогенезе герпетической экземы (экземы капоши)
TL;DR: This review presents an analysis of the literature data on the etiology and pathogenesis of Herpetic Eczema, highlighting the effect of systemic and local immunity, namely, changes in T-cell and interferon system in the development of the pathological process.
Journal ArticleDOI
Longitudinal course and phenotypes of health-related quality of life in adults with atopic dermatitis.
Gabrielle Schwartzman,Donald Lei,Adnan Ahmed,Rajeev Chavda,S Gabriel,Jonathan I. Silverberg,Jonathan I. Silverberg +6 more
TL;DR: In this article, the authors examined predictors, longitudinal course and phenotypes of health-related quality of life (HRQoL) in atopic dermatitis (AD) in adult patients with AD.
References
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Journal ArticleDOI
Severity Scoring of Atopic Dermatitis: The SCORAD Index
K.U. Schallreuter,Ch. Levenig,J. Berger,J. Umbert,R.K. Winkelmann,L. Wegener,O. Correia,Olivier Chosidow,P. Saiag,S. Bastuji-Garin,J. Revuz,Jean-Claude Roujeau,R. Situ,D.R. Inman,S.E.G. Fligiel,J. Varani,R.E. Schopf,J. Dobmeyer,T. Dobmeyer,B. Morsches,K. Holubar,G.E. Piérard,O. Bongard,H. Bounameaux,P. Corcuff,J.-L. Lévêque,J. Brasch,E. Christophers,G.T. Nahass,M. Sisto,S.A. Wagner,R.U. Peter,O. Adam,T. Ruzicka,J. McGrath,N.P. Burrows,R. Russell Jones,R.A.J. Eady,S. Veraldi,G. Rizzitelli,G. Lunghi,R. Cardone,R.M. Trüeb,G. Burg,F. Wantke,G. Fleischl,M. Götz,R. Jarisch,G. Tadini,E. Ermacora,S. Cambiaghi,A. Brusasco,R. Cavalli +52 more
TL;DR: Assessment methods for atopic dermatitis are not standardized, and therapeutic studies are difficult to interpret, so consensus on these methods is needed to obtain a consensus on them.
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