Journal ArticleDOI
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
Jon M. Hanifin,Thurston M,Thurston M,Omoto M,Omoto M,R. Cherill,R. Cherill,Susan J. Tofte,Graeber M,Graeber M +9 more
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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.Abstract:
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.read more
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Journal ArticleDOI
Recent advances in treatment strategies for atopic dermatitis.
TL;DR: A review of the available literature concerning the pharmacological profile and also the level of evidence of therapeutic efficacy of all currently known topical and systemic agents for the treatment of atopic dermatitis reveals a large gap between the knowledge concerning the Pharmacological action in vitro and the evidence of clinical efficacy.
Journal ArticleDOI
Clinical and cytological effects of pimecrolimus cream 1% after resolution of active atopic dermatitis lesions by topical corticosteroids: a randomized controlled trial.
Christine Bangert,Bruce Strober,Michael J. Cork,Jean-Paul Ortonne,Thomas A. Luger,Thomas Bieber,Adam Ferguson,Rupert C. Ecker,Tamara Kopp,Sophia Weise-Riccardi,Achim Guettner,Georg Stingl +11 more
TL;DR: Topical pimecrolimus was effective at maintaining betamethasone-17α-valerate-induced AD remission by inhibiting recurrences of the inflammatory infiltrate in the skin.
Journal ArticleDOI
Product of Investigator Global Assessment and Body Surface Area (IGAxBSA): A practice-friendly alternative to the Eczema Area and Severity Index to assess atopic dermatitis severity in children
Timothy P. Suh,Divya Ramachandran,Vidhi Patel,Kathryn L. Jackson,Stephanie M. Rangel,Anna B. Fishbein,Anna B. Fishbein,Amy S. Paller,Amy S. Paller +8 more
TL;DR: IGAxBSA (using the validated IGA/vIGA) is a simple measure that correlates well with EASI in mild-to-severe pediatric AD, and future work is needed to affirm reliability across IGA scales and responsiveness to change.
Journal ArticleDOI
Tacrolimus clinical studies for atopic dermatitis and other conditions.
J Bergman,M J Rico +1 more
TL;DR: The first topical immunomodulator approved for human use, tacrolimus ointment, has been shown to be effective and safe in the treatment of children and adults with atopic dermatitis (AD) and other skin conditions.
Journal ArticleDOI
Staphylococcus aureus enterotoxins modulate IL-22-secreting cells in adults with atopic dermatitis
Raquel Leão Orfali,Luanda Mara da Silva Oliveira,Josenilson Feitosa de Lima,Gabriel Costa de Carvalho,Yasmim Álefe Leuzzi Ramos,Nátalli Zanete Pereira,Naiura Vieira Pereira,Mariana Colombini Zaniboni,Mirian Nacagami Sotto,Alberto José da Silva Duarte,Maria Notomi Sato,Valeria Aoki +11 more
TL;DR: The hypothesis reinforces the relevance of CD8 T cells modulated by staphylococcal enterotoxins as a potential source of IL-22 in adults with AD, which is relevant for the maintenance of immunological imbalance.
References
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Severity Scoring of Atopic Dermatitis: The SCORAD Index
K.U. Schallreuter,Ch. Levenig,J. Berger,J. Umbert,R.K. Winkelmann,L. Wegener,O. Correia,Olivier Chosidow,P. Saiag,S. Bastuji-Garin,J. Revuz,Jean-Claude Roujeau,R. Situ,D.R. Inman,S.E.G. Fligiel,J. Varani,R.E. Schopf,J. Dobmeyer,T. Dobmeyer,B. Morsches,K. Holubar,G.E. Piérard,O. Bongard,H. Bounameaux,P. Corcuff,J.-L. Lévêque,J. Brasch,E. Christophers,G.T. Nahass,M. Sisto,S.A. Wagner,R.U. Peter,O. Adam,T. Ruzicka,J. McGrath,N.P. Burrows,R. Russell Jones,R.A.J. Eady,S. Veraldi,G. Rizzitelli,G. Lunghi,R. Cardone,R.M. Trüeb,G. Burg,F. Wantke,G. Fleischl,M. Götz,R. Jarisch,G. Tadini,E. Ermacora,S. Cambiaghi,A. Brusasco,R. Cavalli +52 more
TL;DR: Assessment methods for atopic dermatitis are not standardized, and therapeutic studies are difficult to interpret, so consensus on these methods is needed to obtain a consensus on them.
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