Journal ArticleDOI
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
Jon M. Hanifin,Thurston M,Thurston M,Omoto M,Omoto M,R. Cherill,R. Cherill,Susan J. Tofte,Graeber M,Graeber M +9 more
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TLDR
In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.Abstract:
:Objective– To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. Design: Training of evaluators, application, and assessment over 2 consecutive days. Setting– An academic center. Patients– Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients ≥8 years) and cohort 2 (10 patients <8 years). Interventions– None. Main outcome measure– The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. Results– Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. Conclusions– This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.read more
Citations
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The direct cellular target of topically applied pimecrolimus may not be infiltrating lymphocytes
TL;DR: Topically applied calcineurin inhibitors have been shown to be effective in the treatment of atopic dermatitis and when systemically administered, these agents cause immunosuppression via inhibition of calcinesurin in lymphocytes.
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Development and Initial Psychometric Properties of Two Itch-Related Measures: Scratch Intensity and Impact, Sleep-Related Itch and Scratch
TL;DR: Self-report measures are needed to better understand the relationships among sleep, itching, scratching, and chronic itch conditions and their associations with disease severity, quality of life, health, and functioning.
Journal ArticleDOI
Effectiveness and safety of lotion, cream, gel, and ointment emollients for childhood eczema: a pragmatic, randomised, phase 4, superiority trial.
Matthew J Ridd,Miriam Santer,Stephanie J MacNeill,Emily Sanderson,Sian Wells,Douglas Webb,Jonathan Banks,Eileen Sutton,Amanda Roberts,Lyn Liddiard,Zoe Wilkins,Julie Clayton,Kirsty Garfield,Tiffany J Barrett,Jeffrey A. Lane,Helen Baxter,L. Howells,Jodi Taylor,Alastair D Hay,Hywel C Williams,Kim S Thomas +20 more
TL;DR: The authors compared the clinical effectiveness and safety of the four main emollient types: lotions, creams, gels, and ointments, and found no difference in effectiveness between emollients for childhood eczema.
Journal ArticleDOI
The potential pathways underlying the association of propyl-paraben exposure with aeroallergen sensitization and EASI score using metabolomics analysis
Yu Jin Lee,Eun Lee,Dong Keon Yon,Hye Mi Jee,Hey Sung Baek,Seung Won Lee,Joo Youn Cho,Man Yong Han +7 more
TL;DR: In this article, the associations between aeroallergen sensitization and atopic dermatitis (AD) were investigated using untargeted metabolomics analysis and identified the underlying pathways.
Journal ArticleDOI
2019 Consensus Korean Diagnostic Guidelines to Define Severity Classification and Treatment Refractoriness for Atopic Dermatitis: Objective and Subjective Assessment of Severity.
Jung Eun Kim,Min Kyung Shin,Gyeong Hun Park,Un Ha Lee,Ji Hyun Lee,Tae Young Han,Hyun Chang Koh,Yong Hyun Jang,Hye One Kim,Chan Ho Na,Bark Lynn Lew,Ji Young Ahn,Chang Ook Park,Young-Joon Seo,Yang Won Lee,Sang Wook Sohn,Young Lip Park +16 more
TL;DR: KADA built a consensus of definition of moderate and severe AD and treatment-refractoriness to provide a basis for proper treatment strategy and are expected to help physicians determine proper treatment options in need.
References
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Book
The design and analysis of clinical experiments
TL;DR: The Parallel Groups Design as mentioned in this paper is a special case of the Parallel Groups Study, and it is used to control for prognostic variables in linear regression analysis of linear regressions of linear models.
Journal ArticleDOI
Severe psoriasis--oral therapy with a new retinoid.
T. Fredriksson,Ulf Pettersson +1 more
TL;DR: Ro 10--9359 proved to be an extremely potent antipsoriatic drug and a more than 90% reduction of psoriatic lesions could be seen in 10 patients out of 20 after 4-8 weeks of treatment.
Journal ArticleDOI
Severity Scoring of Atopic Dermatitis: The SCORAD Index
K.U. Schallreuter,Ch. Levenig,J. Berger,J. Umbert,R.K. Winkelmann,L. Wegener,O. Correia,Olivier Chosidow,P. Saiag,S. Bastuji-Garin,J. Revuz,Jean-Claude Roujeau,R. Situ,D.R. Inman,S.E.G. Fligiel,J. Varani,R.E. Schopf,J. Dobmeyer,T. Dobmeyer,B. Morsches,K. Holubar,G.E. Piérard,O. Bongard,H. Bounameaux,P. Corcuff,J.-L. Lévêque,J. Brasch,E. Christophers,G.T. Nahass,M. Sisto,S.A. Wagner,R.U. Peter,O. Adam,T. Ruzicka,J. McGrath,N.P. Burrows,R. Russell Jones,R.A.J. Eady,S. Veraldi,G. Rizzitelli,G. Lunghi,R. Cardone,R.M. Trüeb,G. Burg,F. Wantke,G. Fleischl,M. Götz,R. Jarisch,G. Tadini,E. Ermacora,S. Cambiaghi,A. Brusasco,R. Cavalli +52 more
TL;DR: Assessment methods for atopic dermatitis are not standardized, and therapeutic studies are difficult to interpret, so consensus on these methods is needed to obtain a consensus on them.
Journal ArticleDOI
Large sample standard errors of kappa and weighted kappa.
TL;DR: The statistics kappa and weighted kappa (Cohen, 1960) were introduced to provide coefficients of agreement between two raters for nominal scales as discussed by the authors, and they were used to provide a measure of the relative seriousness of the different possible disagreements.
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