E
Ellen A. Tsai
Researcher at Biogen Idec
Publications - 38
Citations - 1274
Ellen A. Tsai is an academic researcher from Biogen Idec. The author has contributed to research in topics: Genome-wide association study & Exome sequencing. The author has an hindex of 13, co-authored 30 publications receiving 640 citations. Previous affiliations of Ellen A. Tsai include University of Pennsylvania & Children's Hospital of Philadelphia.
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Journal ArticleDOI
Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank.
Joseph D. Szustakowski,Suganthi Balasubramanian,Erika Kvikstad,Shareef Khalid,Paola G. Bronson,Ariella Sasson,Emily Wong,Daren Liu,J. Wade Davis,Carolina Haefliger,A. Katrina Loomis,Rajesh Mikkilineni,Hyun Ji Noh,Samir Wadhawan,Xiaodong Bai,Alicia Hawes,Olga Krasheninina,Ricardo Ulloa,Alex Lopez,E. N. Smith,Jeffrey F. Waring,Christopher D. Whelan,Ellen A. Tsai,John D. Overton,William J. Salerno,Howard J. Jacob,Sándor Szalma,Heiko Runz,Gregory Hinkle,Paul Nioi,Slavé Petrovski,Melissa R. Miller,Aris Baras,Lyndon J. Mitnaul,Jeffrey G. Reid +34 more
TL;DR: The UK Biobank Exome Sequencing Consortium (UKB-ESC) as mentioned in this paper is a private-public partnership between the UK Biopartition and eight biopharmaceutical companies that will complete the sequencing of exomes for all ~500,000 UKB participants.
Journal ArticleDOI
Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine
Robert C. Green,Robert C. Green,Katrina A.B. Goddard,Gail P. Jarvik,Laura M. Amendola,Paul S. Appelbaum,Jonathan S. Berg,Barbara A. Bernhardt,Leslie G. Biesecker,Sawona Biswas,Carrie L. Blout,Kevin M. Bowling,Wylie Burke,Charlisse F. Caga-anan,Arul M. Chinnaiyan,Arul M. Chinnaiyan,Wendy K. Chung,Ellen Wright Clayton,Gregory M. Cooper,Kelly M. East,James P. Evans,Stephanie M. Fullerton,Levi A. Garraway,Levi A. Garraway,Jeremy R. Garrett,Jeremy R. Garrett,Stacy W. Gray,Gail E. Henderson,Lucia A. Hindorff,Ingrid A. Holm,Michelle Huckaby Lewis,Carolyn M. Hutter,Pasi A. Jänne,Steven Joffe,David J. Kaufman,Bartha Maria Knoppers,Barbara A. Koenig,Ian D. Krantz,Teri A. Manolio,Laurence B. McCullough,Jean E. McEwen,Amy L. McGuire,Donna M. Muzny,Richard M. Myers,Deborah A. Nickerson,Jeffrey Ou,Donald W. Parsons,Gloria M. Petersen,Sharon E. Plon,Heidi L. Rehm,J. Scott Roberts,Dan R. Robinson,Joseph Salama,Sarah Scollon,Richard R. Sharp,Brian H. Shirts,Nancy B. Spinner,Holly K. Tabor,Peter Tarczy-Hornoch,David L. Veenstra,Nikhil Wagle,Nikhil Wagle,Karen E. Weck,Benjamin S. Wilfond,Kirk C. Wilhelmsen,Susan M. Wolf,Julia Wynn,Joon Ho Yu,Michelle D. Amaral,Samuel J. Aronson,Shubhangi Arora,Danielle R. Azzariti,Greg Barsh,E. M. Bebin,Barbara B. Biesecker,Brian L. Brown,Amber A. Burt,Peter H. Byers,Muge G. Calikoglu,Sara J. Carlson,Nizar Chahin,Kurt D. Christensen,Allison L. Cirino,Laura K. Conlin,Greg M. Cooper,David R. Crosslin,James V. Davis,Kelly Davis,Matthew A. Deardorff,Batsal Devkota,Raymond De Vries,Pamela M. Diamond,Michael O. Dorschner,Noreen P. Dugan,Dmitry Dukhovny,Matthew C. Dulik,Kelly M. East,Edgar A. Rivera-Munoz,Barbara J. Evans,Jessica Everett,Nicole Exe,Zheng Fan,Lindsay Z. Feuerman,Kelly K. Filipski,Candice R. Finnila,Kristen P Fishler,Bob Ghrundmeier,Karen Giles,Marian J. Gilmore,Zahra S. Girnary,Steven Gonsalves,Adam S. Gordon,Michele C. Gornick,William M. Grady,David E. Gray,Robert S. Greenwood,Amanda M. Gutierrez,Paul K. J. Han,Ragan Hart,Patrick J. Heagerty,Naomi Hensman,Susan M. Hiatt,Patricia Himes,Fuki M. Hisama,Carolyn Y. Ho,Lily B. Hoffman-Andrews,Celine Hong,Martha Horike-Pyne,Sara Chandros Hull,Seema M. Jamal,Brian C. Jensen,Jennifer J. Johnston,Dean Karavite,Tia L. Kauffman,Dave Kaufman,Whitley V. Kelley,Jerry H. Kim,Christine Kirby,William M. P. Klein,Sek Won Kong,Joel B. Krier,Neil E. Lamb,Michele P. Lambert,Lan Q. Le,Matthew S. Lebo,Alexander Lee,Kaitlyn B. Lee,Niall J. Lennon,Michael C. Leo,Kathleen A. Leppig,Katie L. Lewis,Neal I. Lindeman,Nicole Lockhart,Bob Lonigro,Edward J. Lose,Philip J. Lupo,Laura Lyman Rodriguez,Frances L. Lynch,Kalotina Machini,Calum A. MacRae,Daniel S. Marchuk,Josue N. Martinez,Aaron J. Masino,Heather M. McLaughlin,Carmit K. McMullen,Piotr A. Mieczkowski,Jeffrey W. Miller,Victoria A. Miller,Rajen Mody,Sean D. Mooney,Elizabeth G. Moore,Elissa Morris,Michael F. Murray,David Ng,Nelly Oliver,Will Parsons,Donald L. Patrick,Jeffrey W. Pennington,Denise L. Perry,Katie Porter,Bradford C. Powell,Sumit Punj,Carmen Radecki Breitkopf,Robin A. Raesz-Martinez,Wendy H. Raskind,Dean A. Reigar,Jacob A. Reiss,Carla A. Rich,Carolyn Sue Richards,Christine Rini,Scott Roberts,Peggy D. Robertson,Jill O. Robinson,Marguerite E. Robinson,Myra I. Roche,Edward J. Romasko,Elisabeth A. Rosenthal,Maria I. Scarano,Jennifer L. Schneider,Christine E. Seidman,Bryce A. Seifert,Brian H. Shirts,Lynette M. Sholl,Javed Siddiqui,Elian Silverman,Shirley Simmons,Janae V. Simons,Debra Skinner,Elena M. Stoffel,Natasha T. Strande,Shamil R. Sunyaev,Virginia P. Sybert,Jennifer M. Taber,Deanne Taylor,Christine R. Tilley,Ashley N. Tomlinson,Susan Brown Trinidad,Ellen A. Tsai,Eliezer M. Van Allen,Jason L. Vassy,Pankaj Vats,Victoria L. Vetter,Raymond De Vries,Sarah A. Walser,Rebecca C. Walsh,Allison Werner-Lin,Jana Whittle,Kirk C. Wilhelmsen,Yaping Yang,Carol Young,Brian J. Zikmund-Fisher +230 more
TL;DR: The CSER consortium is exploring analytic and clinical validity and utility, as well as the ethical, legal, and social implications of sequencing via multidisciplinary approaches; it has recruited 5,577 participants across a spectrum of symptomatic and healthy children and adults by utilizing both germline and cancer sequencing.
Posted ContentDOI
Advancing Human Genetics Research and Drug Discovery through Exome Sequencing of the UK Biobank
Joseph D. Szustakowski,Suganthi Balasubramanian,Ariella Sasson,Shareef Khalid,Paola G. Bronson,Erika Kvikstad,Emily Wong,Daren Liu,J. Wade Davis,Carolina Haefliger,A. Katrina Loomis,Rajesh Mikkilineni,Hyun Ji Noh,Samir Wadhawan,Xiaodong Bai,Alicia Hawes,Olga Krasheninina,Ricardo Ulloa,Alex Lopez,E. N. Smith,Jeff Waring,Christopher D. Whelan,Ellen A. Tsai,John D. Overton,William J. Salerno,Howard Jacob,Sándor Szalma,Heiko Runz,Greg Hinkle,Paul Nioi,Slavé Petrovski,Melissa R. Miller,Aris Baras,Lyndon J. Mitnaul,Jeffrey G. Reid +34 more
TL;DR: Early results from the exome sequence data generated by the UKB-ESC for the first ~200,000 UKB subjects are described and the rationale for the use of human genetics in drug discovery as well as lessons learned are described.
Posted ContentDOI
Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
Wouter van Rheenen,Rick A.A. van der Spek,Mark K Bakker,Joke J.F.A. van Vugt,Paul J. Hop,Ramona A. J. Zwamborn,Niek de Klein,Harm-Jan Westra,Olivier B. Bakker,Patrick Deelen,Patrick Deelen,Gemma Shireby,Eilis Hannon,Matthieu Moisse,Denis Baird,Restuadi Restuadi,Egor Dolzhenko,Annelot M. Dekker,Klara Gawor,Henk-Jan Westeneng,Gijs H.P. Tazelaar,Kristel R. van Eijk,Maarten Kooyman,Ross P. Byrne,Mark A. Doherty,Mark Heverin,Ahmad Al Khleifat,Alfredo Iacoangeli,Alfredo Iacoangeli,Aleksey Shatunov,Nicola Ticozzi,Johnathan Cooper-Knock,Bradley N. Smith,Marta Gromicho,Siddharthan Chandran,Suvankar Pal,Karen E. Morrison,Pamela J. Shaw,John Hardy,Richard W. Orrell,Michael Sendtner,Thomas Meyer,Nazli Basak,Anneke J. van der Kooi,Antonia Ratti,Isabella Fogh,Cinzia Gellera,Giuseppe Lauria Pinter,Stefania Corti,Cristina Cereda,Daisy Sproviero,Sandra D'Alfonso,Gianni Sorarù,Gabriele Siciliano,Massimiliano Filosto,Alessandro Padovani,Adriano Chiò,Andrea Calvo,Cristina Moglia,Maura Brunetti,Antonio Canosa,Maurizio Grassano,Ettore Beghi,Elisabetta Pupillo,Giancarlo Logroscino,Beatrice Nefussy,Alma Osmanovic,Angelica Nordin,Yossef Lerner,Yossef Lerner,Michal Zabari,Michal Zabari,Marc Gotkine,Marc Gotkine,Robert H. Baloh,Shaughn Bell,Patrick Vourc'h,Philippe Corcia,Philippe Couratier,Stéphanie Millecamps,Vincent Meininger,François Salachas,Jesus S. Mora Pardina,Abdelilah Assialioui,Ricardo Rojas-García,Patrick A. Dion,Jay P. Ross,Jay P. Ross,Albert C. Ludolph,Jochen H. Weishaupt,David A. Brenner,Axel Freischmidt,Axel Freischmidt,Gilbert Bensimon,Alexis Brice,Alexandra Durr,Christine Payan,Safa Saker-Delye,Nicholas W. Wood,Simon Topp,Rosa Rademakers,Lukas Tittmann,Wolfgang Lieb,Andre Franke,Stephan Ripke,Stephan Ripke,Stephan Ripke,Alice Braun,Julia Kraft,David C. Whiteman,Catherine M. Olsen,André G. Uitterlinden,Albert Hofman,Marcella Rietschel,Sven Cichon,Markus M. Nöthen,Philippe Amouyel,Bryan J. Traynor,Bryan J. Traynor,Adrew B. Singleton,Miguel Mitne Neto,Ruben J. Cauchi,Roel A. Ophoff,Roel A. Ophoff,Roel A. Ophoff,Martina Wiedau-Pazos,Catherine Lomen-Hoerth,Vivianna M. Van Deerlin,Julian Grosskreutz,A. Rödiger,Nayana Gaur,Alexander Jörk,Tabea Barthel,Erik Theele,Benjamin Ilse,Beatrice Stubendorff,Otto W. Witte,Robert Steinbach,Christian A. Hübner,Caroline Graff,Lev Brylev,Vera Fominykh,Vera Demeshonok,Anastasia Ataulina,Boris Rogelj,Blaž Koritnik,Janez Zidar,Metka Ravnik-Glavač,Damjan Glavač,Zorica Stevic,Vivian E. Drory,Mònica Povedano,Ian P. Blair,Matthew C. Kiernan,Beben Benyamin,Beben Benyamin,Robert D. Henderson,Robert D. Henderson,Sarah Furlong,Susan Mathers,Pamela A. McCombe,Pamela A. McCombe,Merrilee Needham,Merrilee Needham,Merrilee Needham,Shyuan T. Ngo,Garth A. Nicholson,Roger Pamphlett,Dominic B. Rowe,Frederik J. Steyn,Frederik J. Steyn,Kelly L. Williams,Karen A. Mather,Karen A. Mather,Perminder S. Sachdev,Anjali K. Henders,Leanne Wallace,Mamede de Carvalho,Susana Pinto,Susanne Petri,Markus Weber,Guy A. Rouleau,Vincenzo Silani,Charles Curtis,Gerome Breen,Gerome Breen,Jonathan D. Glass,Robert H. Brown,John Landers,Christopher Shaw,Peter M. Andersen,Ewout J N Groen,Michael A. van Es,R. Jeroen Pasterkamp,Dongsheng Fan,Fleur C. Garton,Allan F. McRae,George Davey Smith,Tom R. Gaunt,Michael A. Eberle,Jonathan Mill,Russell L. McLaughlin,Orla Hardiman,Kevin P. Kenna,Naomi R. Wray,Ellen A. Tsai,Heiko Runz,Lude Franke,Ammar Al-Chalabi,Ammar Al-Chalabi,Philip Van Damme,Leonard H. van den Berg,Jan H. Veldink +212 more
TL;DR: All ALS associated signals combined reveal a role for perturbations in vesicle mediated transport and autophagy, and provide evidence for cell-autonomous disease initiation in glutamatergic neurons.
Journal ArticleDOI
Evidence from human and zebrafish that GPC1 is a biliary atresia susceptibility gene.
Shuang Cui,Melissa Leyva–Vega,Ellen A. Tsai,Steven F. EauClaire,Joseph T. Glessner,Hakon Hakonarson,Marcella Devoto,Marcella Devoto,Barbara Haber,Nancy B. Spinner,Randolph P. Matthews +10 more
TL;DR: Based on genetic analysis of patients with BA and zebrafish, GPC1 appears to be a BA susceptibility gene, and these findings support a role for Hedgehog signaling in the pathogenesis of BA.