H
Hiroaki Shimokawa
Researcher at Tohoku University
Publications - 976
Citations - 56856
Hiroaki Shimokawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Heart failure & Endothelium. The author has an hindex of 111, co-authored 949 publications receiving 48822 citations. Previous affiliations of Hiroaki Shimokawa include University of Nebraska Medical Center & Nagoya University.
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Journal ArticleDOI
Colchicine, a microtubule depolymerizing agent, inhibits myocardial apoptosis in rats.
TL;DR: Results indicate that a microtubule-depolymerizing agent could be a potential therapeutic strategy for treatment of heart failure.
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Prognostic Impact of New-Onset Atrial Fibrillation in Patients With Chronic Heart Failure – A Report From the CHART-2 Study –
Takeshi Yamauchi,Yasuhiko Sakata,Masanobu Miura,Soichiro Tadaki,Ryoichi Ushigome,Kenjiro Sato,Takeo Onose,Kanako Tsuji,Ruri Abe,Takuya Oikawa,Shintaro Kasahara,Kotaro Nochioka,Jun Takahashi,Satoshi Miyata,Hiroaki Shimokawa +14 more
TL;DR: Onset of new AF, but not a history of AF, is associated with increased mortality in CHF patients, especially in the first year, and on inverse probability of treatment weighting analysis using propensity score, RAS inhibitors and statins were associated with reduced incidence of newAF, and diuretics wereassociated with increase ofnew AF.
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Endothelium-dependent relaxation in response to aggregating platelets in porcine femoral veins and its modulation by diet.
TL;DR: The protective role of the venous endothelium against aggregating platelets and its modulation by diet is examined and platelet-induced contractions were significantly reduced in rings with endothelio from oil-fed pigs, whereas the contraction levels were comparable in rings without endothelia among the three groups.
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Circadian Variation of Rho-Kinase Activity in Circulating Leukocytes of Patients With Vasospastic Angina
Taro Nihei,Jun Takahashi,Ryuji Tsuburaya,Yoshitaka Ito,Takashi Shiroto,Kiyotaka Hao,Yusuke Takagi,Yasuharu Matsumoto,Masaharu Nakayama,Satoshi Miyata,Yasuhiko Sakata,Kenta Ito,Hiroaki Shimokawa +12 more
TL;DR: Rho-kinase activity exhibits distinct circadian variation associated with alterations in coronary vasomotor responses and autonomic activity in VSA patients, whereas no such variation was noted in non-VSA patients.
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Up-regulated neuronal nitric oxide synthase compensates coronary flow response to bradykinin in endothelial nitric oxide synthase-deficient mice.
M.A. Hassan Talukder,Takako Fujiki,Keiko Morikawa,Minako Motoishi,Hiroshi Kubota,Tsuyoshi Morishita,Masato Tsutsui,Akira Takeshita,Hiroaki Shimokawa +8 more
TL;DR: Results indicate that nN OS compensates coronary flow response to bradykinin in eNOS−/− mice, for which up-regulation of nNOS in VSMCs may be involved.