Hiroaki Shimokawa

TL;DR: Results indicate that hydroxyfasudil-sensitive Rho-kinase-mediated pathway appears to mediate the enhanced MLC phosphorylations (on Ser19 and Ser19/Thr18 residues) and plays a central role in the pathogenesis of coronary artery spasm.

TL;DR: The results showed that the contribution of EDHF to endothelium-dependent relaxations is significantly larger in microvessels than in large arteries; the nature of ED HF may not be a product of cytochrome P450 pathway, while EDHF-induced hyperpolarization is partially mediated by calcium-activated K channels; and aging and hypercholesterolemia significantly impair ED HF-mediated relaxations.

TL;DR: Increased local ACE expression may be important in the pathogenesis of cardiovascular remodeling in this model, as vascular and myocardial remodeling were characterized by increased tissue ACE activities and immunodetectable ACE in those tissues.

TL;DR: The experiments indicate that the protective role of endothelial cells against the vasoconstriction induced by aggregating platelets is depressed in the chronic regenerated state and a lack of responsiveness to serotonin appears to be the cause for the endothelial dysfunction.

TL;DR: Results provide the first evidence that Rho-kinase may be involved in the pathogenesis of the increased peripheral vascular resistance in hypertension in humans.