H
Hiroaki Shimokawa
Researcher at Tohoku University
Publications - 976
Citations - 56856
Hiroaki Shimokawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Heart failure & Endothelium. The author has an hindex of 111, co-authored 949 publications receiving 48822 citations. Previous affiliations of Hiroaki Shimokawa include University of Nebraska Medical Center & Nagoya University.
Papers
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Increased Reactive Oxygen Species in Rostral Ventrolateral Medulla Contribute to Neural Mechanisms of Hypertension in Stroke-Prone Spontaneously Hypertensive Rats
TL;DR: Results suggest that superoxide anions in the RVLM, which generate hydroxyl radicals, are increased inSHRSP and contribute to the neural mechanisms of hypertension in SHRSP.
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Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with chronic thromboembolic pulmonary hypertension.
Koichiro Sugimura,Yoshihiro Fukumoto,Kimio Satoh,Kotaro Nochioka,Yutaka Miura,Tatsuo Aoki,Shunsuke Tatebe,Saori Miyamichi-Yamamoto,Hiroaki Shimokawa +8 more
TL;DR: PTPA is a promising therapeutic option for distal-type CTEPH, which markedly improved pulmonary hemodynamics and pulmonary artery structure, as confirmed by angiography and optical coherence tomography.
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Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries.
Tetsuya Matoba,Hiroaki Shimokawa,Hiroshi Kubota,Keiko Morikawa,Takako Fujiki,Ikuko Kunihiro,Yasushi Mukai,Yoji Hirakawa,Akira Takeshita +8 more
TL;DR: In this article, the authors examined whether H(2)O(2)-derived hyperpolarizing factor (EDHF) is a primary EDHF in human mesenteric arteries with some contribution of gap junctions.
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Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension.
Yasushi Mukai,Hiroaki Shimokawa,Tetsuya Matoba,Tadashi Kandabashi,Shinji Satoh,Junko Hiroki,Kozo Kaibuchi,Akira Takeshita +7 more
TL;DR: The Rho/Rho-kinasepathway plays an important role in regulation of vascular smooth muscle cell (VSMC) contraction and other cellular functions such as proliferation and migration.
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Heart failure as a general pandemic in Asia.
TL;DR: Information regarding the current and future burden of HF in Asia indicates the importance of both primary prevention of underlying diseases of HF and secondary prevention, including management of ischaemic HF, HF with preserved EF, and HF in the elderly.