H
Hiroaki Shimokawa
Researcher at Tohoku University
Publications - 976
Citations - 56856
Hiroaki Shimokawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Heart failure & Endothelium. The author has an hindex of 111, co-authored 949 publications receiving 48822 citations. Previous affiliations of Hiroaki Shimokawa include University of Nebraska Medical Center & Nagoya University.
Papers
More filters
Journal ArticleDOI
Ischemic stroke, hemorrhage, and mortality in patients with non-valvular atrial fibrillation and renal dysfunction treated with rivaroxaban: sub-analysis of the EXPAND study
Hirotsugu Atarashi,Shinichiro Uchiyama,Hiroshi Inoue,Takanari Kitazono,Takeshi Yamashita,Wataru Shimizu,Takanori Ikeda,Masahiro Kamouchi,Koichi Kaikita,Koji Fukuda,Hideki Origasa,Hiroaki Shimokawa +11 more
TL;DR: In this paper, the effectiveness and safety of rivaroxaban in patients with non-valvular atrial fibrillation (NVAF) in routine clinical practice in Japan were investigated.
Journal ArticleDOI
Decreased Bronchial Eosinophilic Inflammation and Mucus Hypersecretion in Asthmatic Mice Lacking All Nitric Oxide Synthase Isoforms
Kentaro Akata,Kazuhiro Yatera,Ke Yong Wang,Keisuke Naito,Takaaki Ogoshi,Shingo Noguchi,Takashi Kido,Yumiko Toyohira,Hiroaki Shimokawa,Nobuyuki Yanagihara,Masato Tsutsui,Hiroshi Mukae +11 more
TL;DR: Using asthmatic n/i/eNOS−/− mice, NO plays important roles in accelerating bronchial eosinophilic inflammation and mucus hypersecretion in the pathophysiology of asthma.
Journal ArticleDOI
Hypertension Promotes Phosphorylation of Focal Adhesion Kinase and Proline-Rich Tyrosine Kinase 2 in Rats: Implication for the Pathogenesis of Hypertensive Vascular Disease
Koichiro Sugimura,Yoshihiro Fukumoto,Jun Nawata,Huan Wang,Noriko Onoue,Tomohiro Tada,Kunio Shirato,Hiroaki Shimokawa +7 more
TL;DR: Results indicate that phosphorylation of FAK and PYK2 is upregulated by elevated blood pressure but not by humoral factors in the rat aorta, demonstrating novel aspects of atherogenesis in hypertension.
Journal ArticleDOI
High-sensitivity C-reactive protein: still need for next-generation biomarkers for remote future cardiovascular events
Kimio Satoh,Hiroaki Shimokawa +1 more
TL;DR: After studying 268 803 Korean men and women, the authors demonstrated that hsCRP levels are much lower in this population than in Caucasians, and showed that the association with future cardiovascular events is stronger in men than in women.
Journal ArticleDOI
Endothelial nitric oxide synthase-independent effects of an ACE inhibitor on coronary flow response to bradykinin in aged mice.
M.A. Hassan Talukder,Takako Fujiki,Keiko Morikawa,Minako Motoishi,Yoko Matsuo,Makoto Hatanaka,Masato Tsutsui,Akira Takeshita,Hiroaki Shimokawa +8 more
TL;DR: Results indicate that coronary flow response to bradykinin is preserved in aged mice even in the absence of eNOS, and an ACE inhibitor augments this response by both eNos-dependent and -independent mechanisms.