H
Hiroaki Shimokawa
Researcher at Tohoku University
Publications - 976
Citations - 56856
Hiroaki Shimokawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Heart failure & Endothelium. The author has an hindex of 111, co-authored 949 publications receiving 48822 citations. Previous affiliations of Hiroaki Shimokawa include University of Nebraska Medical Center & Nagoya University.
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Transforming Growth Factor-β2 and Connective Tissue Growth Factor in Proliferative Vitreoretinal Diseases: Possible Involvement of Hyalocytes and Therapeutic Potential of Rho Kinase Inhibitor
Takeshi Kita,Yasuaki Hata,Kumiko Kano,Muneki Miura,Shintaro Nakao,Yoshihiro Noda,Hiroaki Shimokawa,Tatsuro Ishibashi +7 more
TL;DR: Combined effects of TGF-beta2 and CTGF appear to be involved in the pathogenesis of proliferative vitreoretinal diseases and Hyalocytes may be a possible source of CTGF and thus might play a role in vit reoretinal interface diseases.
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Pathogenic Role of Oxidative Stress in Vascular Angiotensin-Converting Enzyme Activation in Long-Term Blockade of Nitric Oxide Synthesis in Rats
Makoto Usui,Kensuke Egashira,Shiro Kitamoto,Masamichi Koyanagi,Makoto Katoh,Chu Kataoka,Hiroaki Shimokawa,Akira Takeshita +7 more
TL;DR: The results implicate oxidative stress in the pathogenesis of vascular ACE activation in rats with long-term inhibition of NO synthesis and the observed effects of antioxidant drugs on ACE activation do not appear to involve the hypertension induced by L-NAME.
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Spontaneous Myocardial Infarction in Mice Lacking All Nitric Oxide Synthase Isoforms
Sei Nakata,Masato Tsutsui,Hiroaki Shimokawa,Osamu Suda,Tsuyoshi Morishita,Kiyoko Shibata,Yasuko Yatera,Ken Sabanai,Akihide Tanimoto,Machiko Nagasaki,Hiromi Tasaki,Yasuyuki Sasaguri,Yasuhide Nakashima,Yutaka Otsuji,Nobuyuki Yanagihara +14 more
TL;DR: These results provide the first direct evidence that genetic disruption of the whole NOS system causes spontaneous myocardial infarction associated with multiple cardiovascular risk factors of metabolic origin in mice in vivo through the angiotensin II type 1 receptor pathway.
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The parallel tales of microvascular angina and heart failure with preserved ejection fraction: a paradigm shift
Filippo Crea,C. Noel Bairey Merz,John F. Beltrame,Juan Carlos Kaski,Hisao Ogawa,Peter Ong,Udo Sechtem,Hiroaki Shimokawa,Paolo G. Camici +8 more
TL;DR: The prevalence of microvascular angina (MVA) is higher than previously thought and associated with worse clinical outcomes than those observed in asymptomatic subjects with similar risk factor burden.
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Protein Kinase A as Another Mediator of Ischemic Preconditioning Independent of Protein Kinase C
Shoji Sanada,Hiroshi Asanuma,Osamu Tsukamoto,Tetsuo Minamino,Koichi Node,Seiji Takashima,Tomi Fukushima,Akiko Ogai,Yoshiro Shinozaki,Masashi Fujita,Akio Hirata,Hiroko Okuda,Hiroaki Shimokawa,Hitonobu Tomoike,Masatsugu Hori,Masafumi Kitakaze +15 more
TL;DR: Transient preischemic activation of PKA reduces infarct size through Rho-kinase inhibition and actin cytoskeletal deactivation during sustained ischemia, implicating a novel mechanism for cardioprotection by ischemic preconditioning independent of PKC and a potential new therapeutic target.