H
Hiroaki Shimokawa
Researcher at Tohoku University
Publications - 976
Citations - 56856
Hiroaki Shimokawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Heart failure & Endothelium. The author has an hindex of 111, co-authored 949 publications receiving 48822 citations. Previous affiliations of Hiroaki Shimokawa include University of Nebraska Medical Center & Nagoya University.
Papers
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Short-term estrogen augments both nitric oxide-mediated and non-nitric oxide-mediated endothelium-dependent forearm vasodilation in postmenopausal women.
Hirofumi Tagawa,Hiroaki Shimokawa,Tatsuya Tagawa,Mari Kuroiwa-Matsumoto,Yoshitaka Hirooka,Akira Takeshita +5 more
TL;DR: Results indicate that estrogen augments (in the short-term) both NO-mediated and non-NO-mediated endothelium-dependent forearm vasodilation in postmenopausal women, indicating the beneficial effect of estrogen on endothelial vasodilator function appears to extend to non- NO-dependent mechanism(s).
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Pathophysiological relevance of NO signaling in the cardiovascular system: novel insight from mice lacking all NO synthases.
TL;DR: By using the triply NOS(-/-) mice, the roles of the NOS system in endothelium-dependent hyperpolarization and stain-induced NO production have been elucidated and provide novel insight into the cardiovascular role of the endogenous NO/NOS system at the molecular level.
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Prognostic effects of calcium channel blockers in patients with vasospastic angina--a meta-analysis
Kazuhiko Nishigaki,Yukiko Inoue,Yoshio Yamanouchi,Yoshihiro Fukumoto,Satoshi Yasuda,Shozo Sueda,Hidenori Urata,Hiroaki Shimokawa,Shinya Minatoguchi +8 more
TL;DR: In this paper, a meta-analysis regarding the effects of calcium channel blockers (CCB) on major adverse cardiovascular events (MACE) in Japanese VSA patients with the 4 previous studies was performed, showing that among the four major CCB that effectively suppress VSA attacks in general, benidipine showed significantly more beneficial prognostic effects than others.
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Low-intensity pulsed ultrasound induces angiogenesis and ameliorates left ventricular dysfunction in a porcine model of chronic myocardial ischemia.
Kenichiro Hanawa,Kenta Ito,Kentaro Aizawa,Tomohiko Shindo,Kensuke Nishimiya,Yuhi Hasebe,Tuburaya Ryuji,Hideyuki Hasegawa,Satoshi Yasuda,Hiroshi Kanai,Hiroaki Shimokawa +10 more
TL;DR: The results suggest that the LIPUS therapy is promising as a new, non-invasive therapy for IHD.
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Apoptosis induced by inhibition of cyclic AMP response element-binding protein in vascular smooth muscle cells.
Tomotake Tokunou,Rei Shibata,Hisashi Kai,Toshihiro Ichiki,Takashi Morisaki,Kae Fukuyama,Hiroki Ono,Naoko Iino,Satoko Masuda,Hiroaki Shimokawa,Kensuke Egashira,Tsutomu Imaizumi,Akira Takeshita +12 more
TL;DR: Immunohistochemistry revealed that CREB was mainly induced and activated in the neointimal muscle actin–positive cells of rat carotid artery after balloon injury, suggesting that CRE-dependent gene transcription might play an important role in the survival and proliferation of VSMCs.