H
Hiroaki Shimokawa
Researcher at Tohoku University
Publications - 976
Citations - 56856
Hiroaki Shimokawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Heart failure & Endothelium. The author has an hindex of 111, co-authored 949 publications receiving 48822 citations. Previous affiliations of Hiroaki Shimokawa include University of Nebraska Medical Center & Nagoya University.
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Journal ArticleDOI
Statin ameliorates hypoxia-induced pulmonary hypertension associated with down-regulated stromal cell-derived factor-1
Kimio Satoh,Yoshihiro Fukumoto,Makoto Nakano,Koichiro Sugimura,Jun Nawata,Jun Demachi,Akihiko Karibe,Yutaka Kagaya,Naoto Ishii,Kazuo Sugamura,Hiroaki Shimokawa +10 more
TL;DR: It is suggested that pravastatin ameliorates hypoxia-induced PAH through suppression of SDF-1/CXCR4 and ICAM-1 /CD18 pathways with a resultant reduction in the mobilization and homing of BM-derived progenitor cells.
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Plasma cyclophilin A is a novel biomarker for coronary artery disease.
Kimio Satoh,Yoshihiro Fukumoto,Koichiro Sugimura,Yutaka Miura,Tatsuo Aoki,Kotaro Nochioka,Shunsuke Tatebe,Saori Miyamichi-Yamamoto,Toru Shimizu,Shizuka Osaki,Yusuke Takagi,Ryuji Tsuburaya,Yoshitaka Ito,Yasuharu Matsumoto,Masaharu Nakayama,Morihiko Takeda,Jun Takahashi,Kenta Ito,Satoshi Yasuda,Hiroaki Shimokawa +19 more
TL;DR: Plasma CyPA level is a novel biomarker for oxidative stress and CAD in humans and was strongly expressed in coronary atherosclerotic plaque in patients with myocardial infarction.
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Protective Roles of Endothelial AMP-Activated Protein Kinase Against Hypoxia-Induced Pulmonary Hypertension in Mice
Junichi Omura,Kimio Satoh,Nobuhiro Kikuchi,Taijyu Satoh,Ryo Kurosawa,Masamichi Nogi,Tomohiro Otsuki,Katsuya Kozu,Kazuhiko Numano,Kota Suzuki,Shinichiro Sunamura,Shunsuke Tatebe,Tatsuo Aoki,Koichiro Sugimura,Satoshi Miyata,Yasushi Hoshikawa,Yoshinori Okada,Hiroaki Shimokawa +17 more
TL;DR: Endothelial AMPK is a novel therapeutic target for the treatment of PAH and long-term treatment with metformin, an AMPK activator, significantly attenuated hypoxia-induced PH in mice.
Journal ArticleDOI
Fasudil attenuates interstitial fibrosis in rat kidneys with unilateral ureteral obstruction.
S. Satoh,Tamami Yamaguchi,Asako Hitomi,Norihiro Sato,Kazumi Shiraiwa,Ichiro Ikegaki,T. Asano,Hiroaki Shimokawa +7 more
TL;DR: It is suggested that inhibition of Rho-kinase produces a reduction of macrophage infiltration and represents a new therapeutic strategy for renal fibrosis, a major factor in the progression to end-stage renal failure.
Journal ArticleDOI
Coronary Artery Ectasia Predicts Future Cardiac Events in Patients With Acute Myocardial Infarction.
Takahito Doi,Yu Kataoka,Teruo Noguchi,Tatsuhiro Shibata,Takahiro Nakashima,Shoji Kawakami,Kazuhiro Nakao,Masashi Fujino,Toshiyuki Nagai,Tomoaki Kanaya,Yoshio Tahara,Yasuhide Asaumi,Etsuko Tsuda,Michikazu Nakai,Kunihiro Nishimura,Toshihisa Anzai,Kengo Kusano,Hiroaki Shimokawa,Yoichi Goto,Satoshi Yasuda +19 more
TL;DR: The findings suggest that acute MI patients with CAE are a high-risk subset who might benefit from a pharmacological approach to controlling the coagulation cascade.