H
Hiroaki Shimokawa
Researcher at Tohoku University
Publications - 976
Citations - 56856
Hiroaki Shimokawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Heart failure & Endothelium. The author has an hindex of 111, co-authored 949 publications receiving 48822 citations. Previous affiliations of Hiroaki Shimokawa include University of Nebraska Medical Center & Nagoya University.
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Journal Article
Inhibition of Rho-kinase by fasudil prevents anginal attacks associated with spastic angina: A case report
TL;DR: This case suggests that a Rho-kinase inhibitor is potentially effective to prevent anginal attacks in spastic angina, and should be considered for use in elderly patients with unstable angina pectoris.
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Emergence of the erythropoietin/erythropoietin receptor system as a novel cardiovascular therapeutic target.
TL;DR: Results indicate that the vascular Epo/EpoR system plays an important protective role against hypoxia/ischemia, demonstrating that this system is a novel therapeutic target in cardiovascular medicine.
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Prognostic Impact of Diabetes Mellitus in Chronic Heart Failure According to Presence of Ischemic Heart Disease – With Special Reference to Nephropathy –
Masanobu Miura,Yasuhiko Sakata,Satoshi Miyata,Kotaro Nochioka,Tsuyoshi Takada,Soichiro Tadaki,Ryoichi Ushigome,Takeshi Yamauchi,Kenjiro Sato,Takeo Onose,Kanako Tsuji,Ruri Abe,Jun Takahashi,Hiroaki Shimokawa +13 more
TL;DR: The prognostic impact of DM was more evident in patients with IHD than in those without IHD, particularly when complicated with nephropathy, and when the patients were stratified by nephrostathy, DM was associated with worse prognosis only in the IHD patients with ne phropathy.
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Effects of nitric oxide synthase isoform deletion on oxytocin and vasopressin messenger RNA in mouse hypothalamus.
Masayoshi Nomura,Masato Tsutsui,Hiroaki Shimokawa,Naohiro Fujimoto,Yoichi Ueta,Tsuyoshi Morishita,Nobuyuki Yanagihara,Tetsuro Matsumoto +7 more
TL;DR: It is suggested that neuronal nitric-oxide-synthase-derived nitric oxide may be involved in the regulation of oxytocin gene expression in the anterior commissural nucleus of neuronal Nitric oxide synthase knockout mice.
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In vivo magnetic resonance imaging of atherosclerotic lesions with a newly developed Evans blue-DTPA-gadolinium contrast medium in apolipoprotein-E-deficient mice
Satoshi Yasuda,Kenjiro Ikuta,Toyokazu Uwatoku,Keiji Oi,Kohtaro Abe,Fuminori Hyodo,Kengo Yoshimitsu,Kohtaro Sugimura,Hideo Utsumi,Yoshiki Katayama,Hiroaki Shimokawa +10 more
TL;DR: Results indicate that EB-DTPA-Gd is a useful MRI contrast medium for the in vivo detection of atherosclerotic plaques.