H
Hiroaki Shimokawa
Researcher at Tohoku University
Publications - 976
Citations - 56856
Hiroaki Shimokawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Heart failure & Endothelium. The author has an hindex of 111, co-authored 949 publications receiving 48822 citations. Previous affiliations of Hiroaki Shimokawa include University of Nebraska Medical Center & Nagoya University.
Papers
More filters
Journal ArticleDOI
Identification of Adipsin as a Novel Prognostic Biomarker in Patients With Coronary Artery Disease.
Tomohiro Ohtsuki,Kimio Satoh,Toru Shimizu,Shohei Ikeda,Nobuhiro Kikuchi,Taijyu Satoh,Ryo Kurosawa,Masamichi Nogi,Shinichiro Sunamura,Nobuhiro Yaoita,Junichi Omura,Tatsuo Aoki,Shunsuke Tatebe,Koichiro Sugimura,Jun Takahashi,Satoshi Miyata,Hiroaki Shimokawa +16 more
TL;DR: It is indicated that adipsin is a novel biomarker that predicts all‐cause death and rehospitalization in patients with coronary artery disease, demonstrating the novel aspects of the alternative complementary system in the pathogenesis of coronary arteries disease.
Journal ArticleDOI
Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension.
Ryo Kurosawa,Kimio Satoh,Nobuhiro Kikuchi,Haruhisa Kikuchi,Daisuke Saigusa,Elias Al-Mamun,Mohammad Abdul Hai Siddique,Junichi Omura,Taijyu Satoh,Shinichiro Sunamura,Masamichi Nogi,Kazuhiko Numano,Satoshi Miyata,Akira Uruno,Kuniyuki Kano,Yotaro Matsumoto,Takayuki Doi,Junken Aoki,Yoshiteru Oshima,Masayuki Yamamoto,Hiroaki Shimokawa +20 more
TL;DR: Results indicate that celastramycin ameliorates pulmonary hypertension, reducing excessive proliferation of PAH-PASMCs with less inflammation and ROS levels and recovered mitochondrial energy metabolism.
Journal ArticleDOI
Critical role of the Rho-kinase pathway in TGF-β2-dependent collagen gel contraction by retinal pigment epithelial cells
Muneki Miura,Yasuaki Hata,Kumiko Hirayama,Takeshi Kita,Yoshihiro Noda,Kimihiko Fujisawa,Hiroaki Shimokawa,Tatsuro Ishibashi +7 more
TL;DR: Results indicate that TGF-beta2-dependent myofibroblastic transdifferentiation and MLC phosphorylation by RPEs involve both PKC and p38 MAPK pathways at least in part.
Journal ArticleDOI
Glibenclamide, a Selective Inhibitor of ATP-Sensitive K+ Channels, Attenuates Metabolic Coronary Vasodilatation Induced by Pacing Tachycardia in Dogs
Yousuke Katsuda,Kensuke Egashira,Hideki Ueno,Yutaka Akatsuka,Takahiro Narishige,Yukinori Arai,Tsuneo Takayanagi,Hiroaki Shimokawa,Akira Takeshita +8 more
TL;DR: Data indicate that blockade of coronary vascular K+ATP channels with glibenclamide inhibited metabolic coronary vasodilatation induced by pacing tachycardia in dogs, suggesting that K+atP channels are involved in the mechanism mediating metabolic coronary Vasodil atation associated with pacing tachydrocardia.
Journal ArticleDOI
Thrombin-Activatable Fibrinolysis Inhibitor in Chronic Thromboembolic Pulmonary Hypertension
Nobuhiro Yaoita,Kimio Satoh,Taijyu Satoh,Koichiro Sugimura,Shunsuke Tatebe,Saori Yamamoto,Tatsuo Aoki,Masanobu Miura,Satoshi Miyata,Takeshi Kawamura,Hisanori Horiuchi,Yoshihiro Fukumoto,Hiroaki Shimokawa +12 more
TL;DR: Results indicate that plasma levels of TAFI are elevated in patients with CTEPH and are correlated with resistance to clot lysis in those patients, and the extent of clot remaining after 4 hours was improved with an activated TAFi inhibitor.