H
Hiroaki Shimokawa
Researcher at Tohoku University
Publications - 976
Citations - 56856
Hiroaki Shimokawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Heart failure & Endothelium. The author has an hindex of 111, co-authored 949 publications receiving 48822 citations. Previous affiliations of Hiroaki Shimokawa include University of Nebraska Medical Center & Nagoya University.
Papers
More filters
Journal ArticleDOI
Inflammatory cytokines cause coronary arteriosclerosis-like changes and alterations in the smooth-muscle phenotypes in pigs.
Yoshihiro Fukumoto,Hiroaki Shimokawa,Akira Ito,Toshiaki Kadokami,Yoshikazu Yonemitsu,Masanori Aikawa,M. Owada,Kensuke Egashira,Katsuo Sueishi,Ryozo Nagai,Yoshio Yazaki,Akira Takeshita +11 more
TL;DR: Results indicate that inflammatory cytokines all have a similar ability to induce coronary arteriosclerosis-like changes and hyperconstrictive responses, which are associated with alterations in smooth-muscle phenotypes toward dedifferentiation.
Journal ArticleDOI
Prognostic impact of nutritional status in asymptomatic patients with cardiac diseases: a report from the CHART-2 Study.
Kotaro Nochioka,Yasuhiko Sakata,Jun Takahashi,Satoshi Miyata,Masanobu Miura,Tsuyoshi Takada,Yoshihiro Fukumoto,Nobuyuki Shiba,Hiroaki Shimokawa +8 more
TL;DR: In this paper, the authors evaluated the impact of nutrition, using the controlling nutritional status (CONUT) score, calculated by the serum albumin and total cholesterol levels, and lymphocyte number, in 3,421 stage B patients from the Tohoku District-2 Study.
Journal ArticleDOI
Matrix metalloproteinases are involved in mechanical stretch-induced activation of skeletal muscle satellite cells.
Michiko Yamada,Ryuichi Tatsumi,Takashi Kikuiri,Shinpei Okamoto,Shinsuke Nonoshita,Wataru Mizunoya,Yoshihide Ikeuchi,Hiroaki Shimokawa,Kenji Sunagawa,Ronald E. Allen +9 more
TL;DR: Results from these experiments provide strong evidence that MMPs mediate HGF release from the matrix and that this step in the pathway is downstream from NO synthesis.
Journal ArticleDOI
Bradykinin-Induced Vasodilation Is Impaired at the Atherosclerotic Site but Is Preserved at the Spastic Site of Human Coronary Arteries In Vivo
Takeshi Kuga,Kensuke Egashira,Masahiro Mohri,Hiroyuki Tsutsui,Yasuhiko Harasawa,Yoshitoshi Urabe,Shin-ichi Ando,Hiroaki Shimokawa,Akira Takeshita +8 more
TL;DR: It is suggested that bradykinin causes vasodilation of human epicardial coronary arteries in vivo and that bradaykinin-induced endothelium-dependent vasodilated is impaired at the stenotic site but is preserved at the angiographically normal site where endothelia-dependent Vasodilation by acetylcholine is impaired and at the spastic site.
Journal ArticleDOI
Basal Release of Nitric Oxide Is Decreased in the Coronary Circulation in Patients With Heart Failure
Masahiro Mohri,Kensuke Egashira,Tatsuya Tagawa,Takeshi Kuga,Hirofumi Tagawa,Yasuhiko Harasawa,Hiroaki Shimokawa,Akira Takeshita +7 more
TL;DR: Findings suggest that basal release of nitric oxide in the coronary circulation is decreased in patients with heart failure, as indicated by vasoconstricting response to L-NMMA.