H
Hiroaki Shimokawa
Researcher at Tohoku University
Publications - 976
Citations - 56856
Hiroaki Shimokawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Heart failure & Endothelium. The author has an hindex of 111, co-authored 949 publications receiving 48822 citations. Previous affiliations of Hiroaki Shimokawa include University of Nebraska Medical Center & Nagoya University.
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Journal ArticleDOI
Electron Spin Resonance Detection of Hydrogen Peroxide as an Endothelium-Derived Hyperpolarizing Factor in Porcine Coronary Microvessels
Tetsuya Matoba,Hiroaki Shimokawa,Keiko Morikawa,Hiroshi Kubota,Ikuko Kunihiro,Lemmy Urakami-Harasawa,Yasushi Mukai,Yoji Hirakawa,Takaaki Akaike,Akira Takeshita +9 more
TL;DR: ESR evidence is provided that H2O2 is an EDHF in porcine coronary microvessels and bradykinin- or substance P–stimulated intact blood vessels by ESR spectroscopy, which indicates a role for endothelium-derived hyperpolarizing factor in modulating vascular tone.
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Long-term treatment with eicosapentaenoic acid augments both nitric oxide-mediated and non-nitric oxide-mediated endothelium-dependent forearm vasodilatation in patients with coronary artery disease.
Hirofumi Tagawa,Hiroaki Shimokawa,Tatsuya Tagawa,Mari Kuroiwa-Matsumoto,Yoshitaka Hirooka,Akira Takeshita +5 more
TL;DR: Results indicate that long-term treatment with EPA augments both NO-dependent and non-NO-dependent endothelium-dependent forearm vasodilatation in patients with coronary artery disease, and the beneficial effects of EPA appear to extend to non-no-dependent mechanism(s).
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Inflammatory stimuli upregulate Rho-kinase in human coronary vascular smooth muscle cells
Junko Hiroki,Hiroaki Shimokawa,Midoriko Higashi,Keiko Morikawa,Tadashi Kandabashi,Natsumi Kawamura,Toru Kubota,Toshihiro Ichiki,Mutsuki Amano,Kozo Kaibuchi,Akira Takeshita +10 more
TL;DR: The results indicate that the expression and function of Rho-kinase are upregulated by inflammatory stimuli in hcVSMC with an involvement of PKC and NF-kappaB both in vitro and in vivo.
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High-Dose Versus Low-Dose Pitavastatin in Japanese Patients With Stable Coronary Artery Disease (REAL-CAD): A Randomized Superiority Trial
Isao Taguchi,Satoshi Iimuro,Hiroshi Iwata,Hiroaki Takashima,Mitsuru Abe,Eisuke Amiya,Takanori Ogawa,Yukio Ozaki,Ichiro Sakuma,Yoshihisa Nakagawa,Kiyoshi Hibi,Takafumi Hiro,Yoshihiro Fukumoto,Seiji Hokimoto,Katsumi Miyauchi,Tsutomu Yamazaki,Hiroshi Ito,Yutaka Otsuji,Kazuo Kimura,Jun Takahashi,Atsushi Hirayama,Hiroyoshi Yokoi,Kazuo Kitagawa,Takao Urabe,Yasushi Okada,Yasuo Terayama,Kazunori Toyoda,Takehiko Nagao,Masayasu Matsumoto,Yasuo Ohashi,Tetsuji Kaneko,Retsu Fujita,Hiroshi Ohtsu,Hisao Ogawa,Hiroyuki Daida,Hiroaki Shimokawa,Yasushi Saito,Takeshi Kimura,Teruo Inoue,Masunori Matsuzaki,Ryozo Nagai +40 more
TL;DR: The guidelines call for high-intensity statin therapy in patients with cardiovascular disease on the basis of several previous “more versus less statins” trials, however, no clear ev...
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Intramural delivery of a specific tyrosine kinase inhibitor with biodegradable stent suppresses the restenotic changes of the coronary artery in pigs in vivo
Tohru Yamawaki,Hiroaki Shimokawa,Toshiyuki Kozai,Kenji Miyata,Taiki Higo,Eriko Tanaka,Kensuke Egashira,Tadayoshi Shiraishi,Hideo Tamai,Keiji Igaki,Akira Takeshita +10 more
TL;DR: Results indicate that intramural delivery of a specific tyrosine kinase inhibitor with biodegradable stent overcomes the proliferative stimuli caused by balloon injury, the stent itself, and the drug coating on theStent, resulting in the suppression of the restenotic changes of the coronary artery in vivo.