Hiroaki Shimokawa

TL;DR: Dietary supplementation with ω-3 polyunsaturated fatty acids enhances endotheliumdependent relaxations in the basilar artery by two mechanisms: 1) replacement of endogenous arachidonic acid and suppression of the concomitant release of vasoconstrictor prostaglandins from the endothelia, and 2) enhancement of the release of endot Helium-derived relaxing factor.

TL;DR: It is demonstrated, for the first time, that Ang II upregulates nNOS protein expression and activity via AT1R/ROS/eNOS-dependent S-nitrosation and membrane translocation of AT2R.

TL;DR: It has been elucidated that the excess amount of ROS (oxidative stress) promotes VSMC proliferation and potentially develops cardiovascular diseases.

TL;DR: These results provide the first direct evidence that a lack of all three NOS isoforms led to a deterioration of pulmonary fibrosis in a BLM-treated murine model.

TL;DR: Rho-kinase is up-regulated in the aortic wall of human AAA as compared with abdominal aorta from control subjects and the combination therapy with amlodipine and Atorvastatin, but not each monotherapy, suppresses AngII-induced AAA formation in mice in vivo.