H
Hiroaki Shimokawa
Researcher at Tohoku University
Publications - 976
Citations - 56856
Hiroaki Shimokawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Heart failure & Endothelium. The author has an hindex of 111, co-authored 949 publications receiving 48822 citations. Previous affiliations of Hiroaki Shimokawa include University of Nebraska Medical Center & Nagoya University.
Papers
More filters
Journal ArticleDOI
Altered serotonin receptor subtypes mediate coronary microvascular hyperreactivity in pigs with chronic inhibition of nitric oxide synthesis.
Toshiaki Kadokami,Kensuke Egashira,Kouichi Kuwata,Yoshihiro Fukumoto,Toshiyuki Kozai,Hiroshi Yasutake,Takeshi Kuga,Hiroaki Shimokawa,Katsuo Sueishi,Akira Takeshita +9 more
TL;DR: The results suggest that the 5-HT-induced microvascular hyperreactivity may be mediated by relative changes in affinity for 5-hydroxytryptamine receptors or de novo expression of 5- HT1 receptors in microv vascular smooth muscle cells in this animal model.
Journal ArticleDOI
Association of Coronary Perivascular Adipose Tissue Inflammation and Drug-Eluting Stent-Induced Coronary Hyperconstricting Responses in Pigs: 18 F-Fluorodeoxyglucose Positron Emission Tomography Imaging Study.
Kazuma Ohyama,Yasuharu Matsumoto,Hirokazu Amamizu,Hironori Uzuka,Kensuke Nishimiya,Susumu Morosawa,Michinori Hirano,Hiroshi Watabe,Yoshihito Funaki,Satoshi Miyata,Jun Takahashi,Kenta Ito,Hiroaki Shimokawa +12 more
TL;DR: It is indicated for the first time that inflammatory changes of coronary PVAT are associated with drug-eluting stent–induced coronary hyperconstricting responses in pigs in vivo and that 18F-FDG positron emission tomographic/computed tomographic imaging is useful for assessment of Coronary PVAT inflammation.
Journal ArticleDOI
Endothelium-dependent regulation of the cardiovascular system.
TL;DR: The impaired endothelial regulation of the cardiovascular system may have an important implication for the development and progression of many cardiovascular diseases.
Journal ArticleDOI
Changing characteristics of patients with vasospastic angina in the era of new calcium channel blockers.
TL;DR: In the era of new calcium channel blockers, the prognosis of patients with VSA remains good with more prognostic impact of diabetes mellitus, smoking, and a history of myocardial infarction and that benidipine might have some better prognostic effects.
Journal ArticleDOI
Endothelial Gi protein in human coronary arteries
Masato Tsutsui,Hiroaki Shimokawa,Tanaka S,Isao Kuwaoka,Kazunori Hase,Nogami N,Kazuo Nakanishi,Shuichi Okamatsu +7 more
TL;DR: In this paper, the expression of endothelial Gi protein was examined by immunohistochemical staining using a specific antibody against human Gi protein in the proximal segment of the left anterior descending coronary arteries (segment 6) from 40 consecutive autopsy cases.