H
Hiroaki Shimokawa
Researcher at Tohoku University
Publications - 976
Citations - 56856
Hiroaki Shimokawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Heart failure & Endothelium. The author has an hindex of 111, co-authored 949 publications receiving 48822 citations. Previous affiliations of Hiroaki Shimokawa include University of Nebraska Medical Center & Nagoya University.
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Coronary microvascular dysfunction in patients with microvascular angina: analysis by TIMI frame count.
TL;DR: Increased TIMI frame count in response to ACh reflects microvascular dysfunction in MVS and that ISDN may not be enough to relieve MVS, suggesting diffuse impaired coronary microcirculation in the myocardium.
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Prostacyclin does not inhibit rho-kinase: an implication for the treatment of pulmonary hypertension.
Kohtaro Abe,Keiko Morikawa,Takatoshi Hizume,Toyokazu Uwatoku,Keiji Oi,Minoru Seto,Ichiro Ikegaki,Toshio Asano,Kozo Kaibuchi,Hiroaki Shimokawa +9 more
TL;DR: It is suggested that combination therapy with prostacyclin and a Rho-kinase inhibitor could exert further beneficial effects on PH.
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γ-Tocopherol, but not α-tocopherol, potently inhibits neointimal formation induced by vascular injury in insulin resistant rats
Katsuaki Takahashi,Tatsuya Komaru,Satoru Takeda,Morihiko Takeda,Ryoji Koshida,Masaharu Nakayama,Yasunori Kokusho,Yuki Kawakami,Nobuhiro Yamaguchi,Teruo Miyazawa,Hiroaki Shimokawa,Kunio Shirato +11 more
TL;DR: Greek tocopherol, but not α-tocopherol, reduces the neointima proliferation in insulin resistance, independently of its effects on superoxide production and related with its inhibitory effects on nitrosative stress.
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Role of endothelial nitric oxide synthase and collagen metabolism in right ventricular remodeling due to pulmonary hypertension.
Suvd Nergui,Yoshihiro Fukumoto,Zhulanqiqige Do.e,Sota Nakajima,Toru Shimizu,Shohei Ikeda,Md. Elias-Al-Mamun,Hiroaki Shimokawa +7 more
TL;DR: Results indicate that RV remodeling occurs early during PH development through fibrosis, perivascular remodeling, capillary rarefaction and autophagy, in which the eNOS pathway and collagen metabolism might be involved.
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Long-term treatment with nifedipine suppresses coronary hyperconstricting responses and inflammatory changes induced by paclitaxel-eluting stent in pigs in vivo: possible involvement of Rho-kinase pathway.
Ryuji Tsuburaya,Satoshi Yasuda,Takashi Shiroto,Yoshitaka Ito,Jun Yi Gao,Kentaro Aizawa,Yoku Kikuchi,Kenta Ito,Jun Takahashi,Hatsue Ishibashi-Ueda,Hiroaki Shimokawa +10 more
TL;DR: In this article, Paclitaxel-eluting stent (PES) and a BMS were randomly implanted in the left coronary arteries in male domestic pigs with and without long-acting nifedipine (NIF, 4 mg/kg/day) for 4 weeks (n = 7 each).