Hiroaki Shimokawa

TL;DR: The results suggest that the vascular effects of IL-1 beta may also be mediated by FGF-2 in the swine model and that chronic treatment with F GF-2 also causes coronary arteriosclerotic changes and vasospastic responses in vivo.

TL;DR: ESWT may be added to standard treatments for indolent digital ulcers of SSc, as an effective and safe method, and the average scores on the HAQ, EQ-5D, and PainVision system improved.

TL;DR: OLM + AZL may improve the severely impaired EDHF-mediated responses in diabetic ApoE(-/-) mice, in which activation of the endothelial Akt - eNOS pathway may be involved.

TL;DR: In this paper, low-intensity pulsed ultrasound (LIPUS) therapy was used to improve cognitive dysfunction in mouse models of vascular dementia and Alzheimer's disease, and the results indicated that the LIPUS therapy significantly increased the number of CD31-positive blood vessels in the perifocal lesion and doublecortin (DCX)-positive neurons in the ischemic striatum.

TL;DR: It is demonstrated that myelocytic n/i/eNOSs play an important protective role in the pathogenesis of PH, suggesting the involvement of immune and inflammatory mechanisms in the exacerbation of hypoxia‐induced PH caused by n/ i/e NOSs−/−‐BM transplantation.