H
Hiroaki Shimokawa
Researcher at Tohoku University
Publications - 976
Citations - 56856
Hiroaki Shimokawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Heart failure & Endothelium. The author has an hindex of 111, co-authored 949 publications receiving 48822 citations. Previous affiliations of Hiroaki Shimokawa include University of Nebraska Medical Center & Nagoya University.
Papers
More filters
Journal ArticleDOI
A sodium channel blocker, pilsicainide, produces atrial post-repolarization refractoriness through the reduction of sodium channel availability.
Koji Fukuda,Jun Watanabe,Takuya Yagi,Yuji Wakayama,Makoto Nakano,Masateru Kondo,Koji Kumagai,Masahito Miura,Kunio Shirato,Hiroaki Shimokawa +9 more
TL;DR: Results indicate that SCBs produce atrial PRR through the reduction of sodium channel availability, thought to be one of main anti-arrhythmic mechanisms of class I sodium channel blockers (SCBs).
Journal ArticleDOI
Renal Denervation Suppresses Coronary Hyperconstricting Responses After Drug-Eluting Stent Implantation in Pigs In Vivo Through the Kidney–Brain–Heart Axis
Hironori Uzuka,Yasuharu Matsumoto,Kensuke Nishimiya,Kazuma Ohyama,Hideaki Suzuki,Hirokazu Amamizu,Susumu Morosawa,Michinori Hirano,Tomohiko Shindo,Yoku Kikuchi,Kiyotaka Hao,Takashi Shiroto,Kenta Ito,Jun Takahashi,Koji Fukuda,Satoshi Miyata,Yoshihito Funaki,Hatsue Ishibashi-Ueda,Satoshi Yasuda,Hiroaki Shimokawa +19 more
TL;DR: These results provide the first evidence that RDN ameliorates drug-eluting stent–induced coronary hyperconstricting responses in pigs in vivo through the kidney–brain–heart axis.
Journal ArticleDOI
Hyperreactivity of aortic smooth muscle to serotonin is related to the presence of atheroma in Watanabe heritable hyperlipidaemic rabbits
Hirofumi Tagawa,Hitonobu Tomoike,Wataru Mitsuoka,Shinji Satoh,Takeshi Kuga,Hiroaki Shimokawa,Motoomi Nakamura,Akira Takeshita +7 more
TL;DR: Results indicate that medial smooth muscle located beneath the atheroma is specifically hyperreactive to serotonin and that altered protein kinase C activity may explain in part the augmented response to serotonin.
Journal ArticleDOI
Important role of endothelium-dependent hyperpolarization in the pulmonary microcirculation in male mice: implications for hypoxia-induced pulmonary hypertension
Shuhei Tanaka,Takashi Shiroto,Shigeo Godo,Hiroki Saito,Yosuke Ikumi,Akiyo Ito,Shoko Kajitani,Saori Sato,Hiroaki Shimokawa +8 more
TL;DR: It is indicated that EDH plays important roles in the pulmonary microcirculation in addition to NO under normoxic conditions and that impaired EDH-mediated relaxation and subsequent nitrosative stress may be potential triggers of the onset of PH.
Journal ArticleDOI
Diagnostic and Prognostic Significance of Serum Levels of SeP (Selenoprotein P) in Patients With Pulmonary Hypertension.
Nobuhiro Kikuchi,Kimio Satoh,Taijyu Satoh,Nobuhiro Yaoita,Mohammad Abdul Hai Siddique,Junichi Omura,Ryo Kurosawa,Masamichi Nogi,Shinichiro Sunamura,Satoshi Miyata,Hirofumi Misu,Yoshiro Saito,Hiroaki Shimokawa +12 more
TL;DR: Serum SeP is a novel biomarker for diagnosis and assessment of treatment efficacy and long-term prognosis in patients with PAH and is correlated with the absolute change in mean pulmonary artery pressure, pulmonary vascular resistance, and cardiac index.