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Hiroaki Shimokawa
Researcher at Tohoku University
Publications - 976
Citations - 56856
Hiroaki Shimokawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Heart failure & Endothelium. The author has an hindex of 111, co-authored 949 publications receiving 48822 citations. Previous affiliations of Hiroaki Shimokawa include University of Nebraska Medical Center & Nagoya University.
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Journal ArticleDOI
Monocyte-related cytokines in acute myocardial infarction.
Hideki Tashiro,Hiroaki Shimokawa,Kunihiko Yamamoto,Mitunori Nagano,Michiko Momohara,Ko-hei Muramatu,Akira Takeshita +6 more
TL;DR: The results indicate that the concentrations of the monocyte-related cytokines dynamically change during the course of AMI, suggesting that they may contribute to the inflammatory and subsequent proliferative responses in AMI.
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Importance of Rac1 Signaling Pathway Inhibition in the Pleiotropic Effects of HMG-CoA Reductase Inhibitors
TL;DR: The pleiotropic effects of statins, if any, at their clinical doses are mediated predominantly through inhibition of the Rac1 signaling pathway.
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Intensive immunosuppressive therapy improves pulmonary hemodynamics and long-term prognosis in patients with pulmonary arterial hypertension associated with connective tissue disease.
Saori Miyamichi-Yamamoto,Yoshihiro Fukumoto,Koichiro Sugimura,Tomonori Ishii,Kimio Satoh,Yutaka Miura,Shunsuke Tatebe,Kotaro Nochioka,Tatsuo Aoki,Zhulanqiqige Do.e,Hiroaki Shimokawa +10 more
TL;DR: It is suggested that intensive immunosuppressive therapy as well as conventional vasodilator therapy improves the pulmonary hemodynamics and long-term prognosis of patients with CPAH.
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Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension: Possible Novel Therapeutic Target.
Nobuhiro Kikuchi,Kimio Satoh,Ryo Kurosawa,Nobuhiro Yaoita,Md. Elias-Al-Mamun,Mohammad Abdul Hai Siddique,Junichi Omura,Taijyu Satoh,Masamichi Nogi,Shinichiro Sunamura,Satoshi Miyata,Yoshiro Saito,Yasushi Hoshikawa,Yoshinori Okada,Hiroaki Shimokawa +14 more
TL;DR: In this article, excessive proliferation and apoptosis resistance of pulmonary artery smooth muscle cells (PASMCs) are key mechanisms of pulmonary arterial hypertension (PAH), despite the multiple combi...
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Important role of endothelium-derived hyperpolarizing factor in Shear stress-induced endothelium-dependent relaxations in the rat mesenteric artery
Yoshiaki Takamura,Hiroaki Shimokawa,Huiying Zhao,Hirohito Igarashi,Kensuke Egashira,Akira Takeshita +5 more
TL;DR: Results indicate that EDHF plays an important role in shear stress-induced endothelium-dependent relaxations, where K channels, especially calcium-activated K channels), appear to be involved.