Hiroaki Shimokawa

TL;DR: This brief review summarizes the current knowledge about H( 2)O(2) as an EDHF, with special reference to its production by the endothelium, its action on membrane potentials and its pathophysiological roles.

TL;DR: In vivo, fasudil significantly inhibited the progression of experimental PVR in rabbit eyes without affecting the viability of retinal cells by electroretinographic and histological analyses, elucidate the critical role of TGF-β in mediating cicatricial contraction in proliferative vitreoretinal diseases.

TL;DR: It is demonstrated that endothelium-derived H2O2, another reactive oxygen species in addition to NO, plays important roles as a redox-signaling molecule to cause vasodilatation as well as cardioprotection.

TL;DR: This in vitro pilot study prior to in vivo experiments suggests that on-stent cell delivery of EPCs may be novel therapeutic devices for re-endothelialization or endothelium lining or paving at an atherosclerotic arterial wall, resulting in the prevention of on- Stent thrombus formation and in-Stent restenosis, as well as the rapid formation of normal tissue architecture.

TL;DR: The endothelium‐dependent actions of prostacyclin probably reflect activation of adenylate cyclase, and the relaxations induced by prostacyClin or forskolin also had an endothelia‐dependent component in basilar and femoral arteries and in jugular veins of the pig.