H
Hiroaki Shimokawa
Researcher at Tohoku University
Publications - 976
Citations - 56856
Hiroaki Shimokawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Heart failure & Endothelium. The author has an hindex of 111, co-authored 949 publications receiving 48822 citations. Previous affiliations of Hiroaki Shimokawa include University of Nebraska Medical Center & Nagoya University.
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Low-energy extracorporeal shock wave therapy promotes BDNF expression and improves functional recovery after spinal cord injury in rats
Michiharu Matsuda,Haruo Kanno,Takehiro Sugaya,Seiji Yamaya,Kenichiro Yahata,Kyoichi Handa,Tomohiko Shindo,Hiroaki Shimokawa,Hiroshi Ozawa,Eiji Itoi +9 more
TL;DR: Findings indicate that low-energy ESWT promotes BDNF expression at the lesion site and reduces the neural tissue damage and functional impairment following spinal cord injury.
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Rho-kinase as a novel gene therapeutic target in treatment of cold ischemia/reperfusion-induced acute lethal liver injury: effect on hepatocellular NADPH oxidase system.
Satoko Shiotani,Mitsuo Shimada,Akinobu Taketomi,Yuji Soejima,Tomoharu Yoshizumi,Kohji Hashimoto,Hiroaki Shimokawa,Yoshihiko Maehara +7 more
TL;DR: The results suggest that Rho-kinase-mediated pathway plays a crucial role in the ROS production through NADPH oxidase in hepatocytes during the hyperacute phase of reperfusion in vivo, and may be a new therapeutic target for the prevention of primary graft failure in liver transplantation.
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A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk
Stephen A. Williams,Rachel Ostroff,Michael A Hinterberg,Josef Coresh,Christie M. Ballantyne,Kunihiro Matsushita,Christian Mueller,Joan Walter,Christian Jonasson,Rury R. Holman,Svati H. Shah,Naveed Sattar,Roy Taylor,Michael E Lean,Shintaro Kato,Hiroaki Shimokawa,Yasuhiko Sakata,Kotaro Nochioka,Chirag R. Parikh,Steven G. Coca,Torbjørn Omland,Jessica Chadwick,David P. Astling,Yolanda Hagar,Natasha Kureshi,Kelsey M. Loupy,Clare Paterson,Jeremy Primus,Missy Simpson,Nelson Trujillo,Peter Ganz +30 more
TL;DR: This model was validated across more than 11,000 participants from multiple large studies and was sensitive to both adverse and beneficial changes in outcome, suggesting that it has potential as a surrogate end point for use in phase 2 trials.
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Prognostic Links Between OCT-Delineated Coronary Morphologies and Coronary Functional Abnormalities in Patients With INOCA.
Kensuke Nishimiya,Akira Suda,Kento Fukui,Kiyotaka Hao,Jun Takahashi,Yasuharu Matsumoto,Kiyoto Mitsuishi,Tasuku Watanabe,Kazuma Ohyama,Jun Sugisawa,Satoshi Tsuchiya,Koichi Satoh,Tomohiko Shindo,Shigeo Godo,Yoku Kikuchi,Takashi Shiroto,Satoshi Yasuda,Hiroaki Shimokawa +17 more
TL;DR: In this article, the authors examined whether there are prognostic links between coronary morphologies and coronary functional abnormalities in ischemia and nonobstructive coronary artery disease (INOCA) patients.
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Recent Advances in the Development of Cardiovascular Biomarkers.
Kimio Satoh,Hiroaki Shimokawa +1 more
TL;DR: The authors’ previous work on biomarkers of oxidative stress provided evidence for potential pathways that may explain the link between air pollution exposure and acute cardiovascular events, and novel research in the field of biomarkers for CVD is highlighted.