H
Hiroaki Shimokawa
Researcher at Tohoku University
Publications - 976
Citations - 56856
Hiroaki Shimokawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Heart failure & Endothelium. The author has an hindex of 111, co-authored 949 publications receiving 48822 citations. Previous affiliations of Hiroaki Shimokawa include University of Nebraska Medical Center & Nagoya University.
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Journal ArticleDOI
Endothelial AMP-Activated Protein Kinase Regulates Blood Pressure and Coronary Flow Responses Through Hyperpolarization Mechanism in Mice
Budbazar Enkhjargal,Shigeo Godo,Ayuko Sawada,Nergui Suvd,Hiroki Saito,Kazuki Noda,Kimio Satoh,Hiroaki Shimokawa +7 more
TL;DR: These results provide the first direct evidence that &agr;1 subunit of eAMPK substantially mediates EDH responses of microvessels and regulates blood pressure and coronary flow responses in mice in vivo, demonstrating the novel role of eampK in cardiovascular homeostasis.
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Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice.
Mika Kina-Tanada,Mayuko Sakanashi,Akihide Tanimoto,Tadashi Kaname,Toshihiro Matsuzaki,Katsuhiko Noguchi,Taro Uchida,Junko Nakasone,Chisayo Kozuka,Masayoshi Ishida,Haruaki Kubota,Yuji Taira,Yuichi Totsuka,Shin ichiro Kina,Hajime Sunakawa,Junichi Omura,Kimio Satoh,Hiroaki Shimokawa,Nobuyuki Yanagihara,Shiro Maeda,Yusuke Ohya,Masayuki Matsushita,Hiroaki Masuzaki,Akira Arasaki,Masato Tsutsui +24 more
TL;DR: These results provide the first evidence that long-term dietary nitrite/nitrate deficiency gives rise to the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice, indicating a novel pathogenetic role of the exogenous NO production system in the metabolic Syndrome and its vascular complications.
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Acute myocardial infarction: the enduring challenge for cardiac protection and survival.
Satoshi Yasuda,Hiroaki Shimokawa +1 more
TL;DR: An effective pre-hospital lifeline system should be an important priority, achieved through the chain of survival, including the immediate implementation of definitive resuscitative efforts and rapidly transporting the patients to the hospital.
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Altered plasma levels of cytokines in patients with ischemic heart disease.
Hideki Tashiro,Hiroaki Shimokawa,Kunihiko Yamamoto,Michiko Momohara,Hideo Tada,Akira Takeshita +5 more
TL;DR: The present results suggest that the alterations in the plasma levels of MCSF and TGF-beta may be involved in the pathogenesis of IHD in humans.
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Crucial role of rho-kinase in pressure overload-induced right ventricular hypertrophy and dysfunction in mice
Shohei Ikeda,Kimio Satoh,Nobuhiro Kikuchi,Satoshi Miyata,Kota Suzuki,Junichi Omura,Toru Shimizu,Kenta Kobayashi,Kazuto Kobayashi,Yoshihiro Fukumoto,Yasuhiko Sakata,Hiroaki Shimokawa +11 more
TL;DR: Results indicate that the Rho-kinase pathway plays a crucial role in RV hypertrophy and dysfunction, suggesting that the pathway is a novel therapeutic target of RV failure in humans.