H
Hiroaki Shimokawa
Researcher at Tohoku University
Publications - 976
Citations - 56856
Hiroaki Shimokawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Heart failure & Endothelium. The author has an hindex of 111, co-authored 949 publications receiving 48822 citations. Previous affiliations of Hiroaki Shimokawa include University of Nebraska Medical Center & Nagoya University.
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Divergent effects of estrogen and nicotine on Rho-kinase expression in human coronary vascular smooth muscle cells.
TL;DR: In this article, it was shown that inflammatory stimuli up-regulated Rho-kinase plays an important role in the pathogenesis of coronary arteriosclerosis and vasospasm.
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Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload.
Shohei Ikeda,Shohei Ikeda,Wataru Mizushima,Sebastiano Sciarretta,Sebastiano Sciarretta,Maha Abdellatif,Peiyong Zhai,Risa Mukai,Nadezhda Fefelova,Shin Ichi Oka,Michinari Nakamura,Dominic P. Del Re,Iain K. Farrance,Ji Yeon Park,Bin Tian,Lai-Hua Xie,Mohit Kumar,Chiao Po Hsu,Sakthivel Sadayappan,Hiroaki Shimokawa,Dae-Sik Lim,Junichi Sadoshima +21 more
TL;DR: Although activation of YAP promotes cardiomyocyte regeneration after cardiac injury, it induces cardiomeocyte dedifferentiation and heart failure in the long-term in the presence of PO through activation of the YAP-TEAD1-OSM positive feedback mechanism.
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The involvement of the rho-kinase pathway and its regulation in cytokine-induced collagen gel contraction by hyalocytes.
Kumiko Hirayama,Yasuaki Hata,Yoshihiro Noda,Muneki Miura,Ichiro Yamanaka,Hiroaki Shimokawa,Tatsuro Ishibashi +6 more
TL;DR: The hyalocytes have a contractile property in the presence of PDGF-BB and TGF- beta2, and sustained activation of the Rho-kinase pathway and myofibroblast-like transdifferentiation appears to be involved in the T GF-beta2-dependent contractile properties of hyalocyte.
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Disruption of Inducible Nitric Oxide Synthase Improves β-Adrenergic Inotropic Responsiveness but Not the Survival of Mice With Cytokine-Induced Cardiomyopathy
Hajime Funakoshi,Toru Kubota,Natsumi Kawamura,Yoji Machida,Arthur M. Feldman,Hiroyuki Tsutsui,Hiroaki Shimokawa,Akira Takeshita +7 more
TL;DR: The results indicate that although myocardial expression of iNOS plays a key role in the attenuation ofrenergic inotropic responsiveness, NO-independent mechanisms might be more important in the development of congestive heart failure.
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ApoE gene deficiency enhances the reduction of bone formation induced by a high-fat diet through the stimulation of p53-mediated apoptosis in osteoblastic cells.
Hideyuki Hirasawa,Shinya Tanaka,Akinori Sakai,Masato Tsutsui,Hiroaki Shimokawa,Hironori Miyata,Sawako Moriwaki,Shumpei Niida,Masako Ito,Toshitaka Nakamura +9 more
TL;DR: Osteoblast apoptosis increased in the tibias of apoE−/− mice fed with a high‐fat diet, decreasing bone formation, and the expression of p53 mRNA in marrow adherent cells increased.