H
Hiroaki Shimokawa
Researcher at Tohoku University
Publications - 976
Citations - 56856
Hiroaki Shimokawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Heart failure & Endothelium. The author has an hindex of 111, co-authored 949 publications receiving 48822 citations. Previous affiliations of Hiroaki Shimokawa include University of Nebraska Medical Center & Nagoya University.
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Journal ArticleDOI
Important Role of Endogenous Erythropoietin System in Recruitment of Endothelial Progenitor Cells in Hypoxia-Induced Pulmonary Hypertension in Mice
Kimio Satoh,Yutaka Kagaya,Makoto Nakano,Yoshitaka Ito,Jun Ohta,Hiroko Tada,Akihiko Karibe,Naoko Minegishi,Norio Suzuki,Masayuki Yamamoto,Masao Ono,Jun Watanabe,Kunio Shirato,Naoto Ishii,Kazuo Sugamura,Hiroaki Shimokawa +15 more
TL;DR: The results indicate that the endogenous Epo/EpoR system plays an important role in the recruitment of EPCs and prevents the development of PH during chronic hypoxia in mice in vivo, suggesting the therapeutic importance of the system for the treatment of PH.
Journal Article
Antianginal effect of fasudit, a Rho-kinase inhibitor, in patients with stable effort angina : a multicenter study
TL;DR: Fasudil was well tolerated in both trials without any serious adverse reactions and a significant dose-response relation was noted across the treatment groups for the exercise tolerance index that was determined by the combined effect of exercise time and ST segment depression.
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Clinical implications of provocation tests for coronary artery spasm: safety, arrhythmic complications, and prognostic impact: multicentre registry study of the Japanese Coronary Spasm Association.
Yusuke Takagi,Satoshi Yasuda,Jun Takahashi,Ryusuke Tsunoda,Yasuhiro Ogata,Atsushi Seki,Tetsuya Sumiyoshi,Motoyuki Matsui,Toshikazu Goto,Yasuhiko Tanabe,Shozo Sueda,Toshiaki Sato,Satoshi Ogawa,Norifumi Kubo,Shin-ichi Momomura,Hisao Ogawa,Hiroaki Shimokawa +16 more
TL;DR: The spasm provocation tests have an acceptable level of safety and the evaluation of spasm type may provide useful information for the risk prediction of VSA patients.
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Natural course of the impairment of endothelium-dependent relaxations after balloon endothelium removal in porcine coronary arteries. Possible dysfunction of a pertussis toxin-sensitive G protein.
TL;DR: Endothelium-dependent relaxations progressively worsen after regeneration of the endothelium and that the dysfunction of a pertussis toxin-sensitive G protein partly account for the endothelial dysfunction in the chronic regenerated state is indicated.
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Extracorporeal cardiac shock wave therapy ameliorates myocardial ischemia in patients with severe coronary artery disease
Yoshihiro Fukumoto,Akira Ito,Toyokazu Uwatoku,Tetsuya Matoba,Takuya Kishi,Haruki Tanaka,Akira Takeshita,Kenji Sunagawa,Hiroaki Shimokawa,Hiroaki Shimokawa +9 more
TL;DR: The results indicate that the extracorporeal cardiac shock wave therapy is an effective and non-invasive treatment for end-stage coronary artery disease, although further careful evaluation is needed.