H
Hiroaki Shimokawa
Researcher at Tohoku University
Publications - 976
Citations - 56856
Hiroaki Shimokawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Heart failure & Endothelium. The author has an hindex of 111, co-authored 949 publications receiving 48822 citations. Previous affiliations of Hiroaki Shimokawa include University of Nebraska Medical Center & Nagoya University.
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The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice
Shunsuke Eba,Yasushi Hoshikawa,Takashi Moriguchi,Yoichiro Mitsuishi,Hironori Satoh,Kazuyuki Ishida,Tatsuaki Watanabe,Toru Shimizu,Hiroaki Shimokawa,Yoshinori Okada,Masayuki Yamamoto,Takashi Kondo +11 more
TL;DR: The efficacy of oltipraz highlights a promising therapeutic potency of Nrf2 activators for the prevention of PH in patients with hypoxemic lung disease and the decreased antioxidant enzymes may underlie the pathogenesis of cardiopulmonary changes in the patient with chronic obstructive pulmonary disease and PH.
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Thrombin Induces Interleukin-6 Expression Through the cAMP Response Element in Vascular Smooth Muscle Cells
Tomotake Tokunou,Toshihiro Ichiki,Kotaro Takeda,Yuko Funakoshi,Naoko Iino,Hiroaki Shimokawa,Kensuke Egashira,Akira Takeshita +7 more
TL;DR: Results suggest that the CRE site and CREB play an important role in thrombin-induced IL-6 gene expression in VSMCs and may be a novel transcription factor that regulates throm bin-induced gene expression.
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Diverse Functions of Endothelial NO Synthases System: NO and EDH.
Hiroaki Shimokawa,Shigeo Godo +1 more
TL;DR: The diverse functions of endothelial NOSs system with NO and EDH/H2O2 could account for a compensatory mechanism in the setting of endothelium dysfunction.
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Beneficial effect of hydroxyfasudil, a specific Rho-kinase inhibitor, on ischemia/reperfusion injury in canine coronary microcirculation in vivo
Toyotaka Yada,Hiroaki Shimokawa,Osamu Hiramatsu,Tatsuya Kajita,Fumiyuki Shigeto,Etsuro Tanaka,Yoshiro Shinozaki,Hidezo Mori,Takahiko Kiyooka,Masashi Katsura,Seitaro Ohkuma,Masami Goto,Yasuo Ogasawara,Fumihiko Kajiya +13 more
TL;DR: Hydxyfasudil exerts cardioprotective effects on coronary I/R injury in vivo, in which NO-mediated mechanism may be involved through preservation of eNOS expression.
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Significance of nitric oxide synthases: Lessons from triple nitric oxide synthases null mice.
Masato Tsutsui,Akihide Tanimoto,Masahito Tamura,Hiroshi Mukae,Nobuyuki Yanagihara,Hiroaki Shimokawa,Yutaka Otsuji +6 more
TL;DR: Evidence is provided that NOSs play pivotal roles in the pathogenesis of a wide variety of disorders, based on lessons learned from experiments with the triple mutant model of mice generated.